Institute of Environmental and Food Safety , Wuhan Academy of Agricultural Science and Technology , Wuhan 430207 , People's Republic of China.
ACS Appl Mater Interfaces. 2018 May 2;10(17):14665-14672. doi: 10.1021/acsami.8b00702. Epub 2018 Apr 17.
An efficient and facile metal-organic framework (MOF)-template strategy for preparing carbon nanocomposites has been developed. First of all, a series of metal ions, including Fe, Zr, and La, were respectively connected with 2-aminoterephthalate (HATA) to form three metal-organic frameworks (MOFs) and then three novel MOF-derived materials were obtained by annealing them at 550 °C under N atmosphere. The morphologies and microstructure results showed that they still retained the original structure of MOFs and formed carbon-supported metal oxide hybrid nanomaterials. Interestingly, it was found that La-MOF-NH and its derived materials were first reported, which had wool-ball-like structure formed by many streaky-shaped particles intertwining each other. Furthermore, these MOF-derived materials were all successfully used as effective immobilization matrixes of acetylcholinesterase (AChE) to construct biosensors for the detection of methyl parathion. Especially, [La-MOF-NH] with wool-ball-like structure not only provided more active sites of multicontents to increase AChE immobilization amount but also facilitated the accessibility of electron transfer and shorten their diffusion length on the surface of electrode. Under optimal conditions, the biosensor based on [La-MOF-NH] displayed the widest linear range of 1.0 × 10-5.0 × 10 g mL and the lowest detection limit of 5.8 × 10 g mL in three biosensors. This study illustrates the feasibility and the potential of a series of MOF-derived materials for biosensors with improved electrochemical performance.
一种高效简便的金属-有机骨架（MOF）-模板策略已被开发用于制备碳纳米复合材料。首先，一系列金属离子，包括 Fe、Zr 和 La，分别与 2-氨基对苯二甲酸（HATA）连接，形成三种金属-有机骨架（MOFs），然后在 N 气氛下于 550°C 退火得到三种新型 MOF 衍生材料。形貌和微观结构结果表明，它们仍然保留了 MOFs 的原始结构，并形成了碳负载金属氧化物杂化纳米材料。有趣的是，发现 La-MOF-NH 及其衍生材料是首次报道的，其具有由许多条状颗粒相互缠绕形成的羊毛球状结构。此外，这些 MOF 衍生材料都成功地用作乙酰胆碱酯酶（AChE）的有效固定化基质，用于构建用于检测甲基对硫磷的生物传感器。特别是具有羊毛球状结构的[La-MOF-NH]不仅提供了更多的多组分活性位点来增加 AChE 的固定化量，而且还促进了电子转移的可及性并缩短了它们在电极表面上的扩散长度。在最佳条件下，基于[La-MOF-NH]的生物传感器在三个生物传感器中显示出最宽的线性范围为 1.0×10-5.0×10 g mL 和最低检测限为 5.8×10 g mL。本研究说明了一系列 MOF 衍生材料在具有改进的电化学性能的生物传感器中的可行性和潜力。
