Centre for the AIDS Programme of Research in South Africa (CAPRISA), Nelson R Mandela School of Medicine, University of KwaZulu-Natal, Durban, South Africa.
School of Public Health, University of the Western Cape, Cape Town, South Africa.
PLoS One. 2018 Apr 5;13(4):e0195107. doi: 10.1371/journal.pone.0195107. eCollection 2018.
Young women are at high risk for negative sexual health outcomes. Despite their high risk, many sexually-active women never experience negative sexual health outcomes. This study explored the ecological risk factors associated with the risk profiles of sexually-active female high school-learners in rural KwaZulu-Natal, South Africa.
Using baseline data from N = 596 sexually-active school-going women, we explored the ecological factors associated with being sexually-active and managing risk successfully [SARS] or unsuccessfully [SARU]. Generalised estimated equations (GEE) were applied to data collected at multiple levels while adjusting for school and other included variables. GEE were used to calculate probability of being SARU.
Amongst SARU learners, 21.9% had HIV, 38.6% had HSV-2, 12.5% were pregnant, 28.7% self-reported STI symptoms and 51.9% reported a previous pregnancy. Individual-level factors had the greatest impact on being SARU. Univariate and multivariate analysis highlighted several important partner factors associated with SARU. Age was significantly associated with the risk profiles (p<0.0001), a greater proportion of SARU learners were 18 or older compared to the SARS learners. The odds of being SARU decreased when ≥18 years (aOR = 0.2577, 95% CI 0.1462-0.4542) or if not falling pregnant was important (aOR = 0.6343, 95% CI 0.4218-0.9538). Having >1 HIV test (aOR = 2.2161, 95% CI 1.3964-3.5169) increased the odds a SARU profile.
Individual and partner level factors are important for the sexual health profile of an adolescent female. While the exploratory findings require further research; managing multiple sexual health outcomes, tailoring responses around a risk profile and including partners is essential for successful interventions.
年轻女性面临着不良性健康结局的高风险。尽管风险很高,但许多有性行为的女性从未经历过不良性健康结局。本研究探讨了与南非夸祖鲁-纳塔尔省农村地区有性行为的高中女生风险特征相关的生态风险因素。
使用 N=596 名有性行为的在校女生的基线数据,我们探讨了与有性行为和成功[艾滋病相关综合征(SARS)]或不成功[艾滋病相关综合征未缓解(SARU)]管理风险相关的生态因素。在调整了学校和其他纳入变量后,使用广义估计方程(GEE)对多水平数据进行分析。GEE 用于计算成为 SARU 的概率。
在 SARU 学习者中,21.9%的人感染了 HIV,38.6%的人感染了单纯疱疹病毒 2 型,12.5%的人怀孕,28.7%的人自我报告有性传播感染症状,51.9%的人报告有过怀孕。个体层面的因素对成为 SARU 的影响最大。单变量和多变量分析突出了与 SARU 相关的几个重要伴侣因素。年龄与风险特征显著相关(p<0.0001),与 SARS 学习者相比,SARU 学习者中年龄在 18 岁或以上的比例更大。当年龄在 18 岁或以上(比值比[OR] = 0.2577,95%置信区间[CI] 0.1462-0.4542)或怀孕不重要时(OR = 0.6343,95%CI 0.4218-0.9538),成为 SARU 的可能性降低。进行了>1 次 HIV 检测(OR = 2.2161,95%CI 1.3964-3.5169)增加了 SARU 风险特征的可能性。
个体和伴侣层面的因素对青少年女性的性健康特征很重要。虽然探索性发现需要进一步研究,但管理多种性健康结局,根据风险特征量身定制应对措施并包括伴侣,对于成功的干预措施至关重要。