Bourbour Samane, Beheshti Maryam, Kazemian Hossein, Bahador Abbas
Department of Medical Microbiology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
Infect Disord Drug Targets. 2018;18(3):183-191. doi: 10.2174/1871526518666180405155327.
RNA interference (RNAi) or Post-Transcriptional Gene Silencing is a strong mechanism of gene silencing which is moderated by MicroRNAs (miRNAs), underlying many fields of eukaryotic biology. The miRNAs are small noncoding RNAs and a gene regulation expression system which showing a tissue-specific expression pattern, and inhibits protein synthesis. For the first time, miRNA has been seen in Caenorhabditis elegans. They play an important role in signaling pathways of various diseases especially periodontal disease during periodontal inflammation and oral cancers. The most important miRNAs in periodontal diseases and oral squamous cell carcinoma are miR-142-3p, miR-146a, miR-155, miR-203, and miR- 223. One of the most important diseases in association with gingival infectious is periodontal diseases which if left untreated, would lead to tooth loss. Hence, the aim of the present study is to focus the effects of miRNAs and their targets in diseases which are mentioned above.
RNA干扰（RNAi）或转录后基因沉默是一种强大的基因沉默机制，由微小RNA（miRNA）调节，是许多真核生物学领域的基础。miRNA是小的非编码RNA，是一种基因调控表达系统，具有组织特异性表达模式，并抑制蛋白质合成。miRNA首次在秀丽隐杆线虫中被发现。它们在各种疾病的信号通路中发挥重要作用，尤其是在牙周炎症和口腔癌期间的牙周疾病中。牙周疾病和口腔鳞状细胞癌中最重要的miRNA是miR-142-3p、miR-146a、miR-155、miR-203和miR-223。与牙龈感染相关的最重要疾病之一是牙周疾病，如果不治疗，会导致牙齿脱落。因此，本研究的目的是关注miRNA及其靶点在上述疾病中的作用。
