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伏立康唑与米卡芬净对来自不同地理区域的耐唑类烟曲霉临床分离株的体外联合研究

In vitro combination of voriconazole with micafungin against azole-resistant clinical isolates of Aspergillus fumigatus from different geographical regions.

作者信息

Fakhim Hamed, Vaezi Afsane, Dannaoui Eric, Sharma Cheshta, Mousavi Bita, Chowdhary Anuradha, Meis Jacques F, Badali Hamid

机构信息

Department of Medical Parasitology and Mycology, Faculty of Medicine, Urmia University of Medical Sciences, Urmia, Iran; Cellular and Molecular Research Center, Urmia University of Medical Sciences, Urmia, Iran.

Department of Medical Mycology, School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran; Student Research Committee, Mazandaran University of Medical Sciences, Sari, Iran.

出版信息

Diagn Microbiol Infect Dis. 2018 Jul;91(3):266-268. doi: 10.1016/j.diagmicrobio.2018.03.003. Epub 2018 Mar 8.

DOI:10.1016/j.diagmicrobio.2018.03.003
PMID:29622284
Abstract

In vitro interaction of voriconazole with micafungin was evaluated against 33 clinical Aspergillus fumigatus isolates, including azole-resistant (n=31) and -susceptible (n=2) isolates. Interaction was synergistic for only 1 resistant isolate carrying the TR/L98H mutation. No antagonistic effects were observed for 96.8% of azole-resistant isolates.

摘要

在体外评估了伏立康唑与米卡芬净对33株临床烟曲霉分离株的相互作用，其中包括唑类耐药（n = 31）和敏感（n = 2）分离株。仅对1株携带TR/L98H突变的耐药分离株表现出协同作用。96.8%的唑类耐药分离株未观察到拮抗作用。

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