一种新型荧光4-氨基-1,8-萘二甲酰亚胺特罗格碱-Ru（II）-姜黄素有机金属共轭物的合成、结构表征及抗增殖活性
Synthesis, structural characterisation and antiproliferative activity of a new fluorescent 4-amino-1,8-naphthalimide Tröger's base-Ru(ii)-curcumin organometallic conjugate.
作者信息
Shanmugaraju Sankarasekaran, la Cour Poulsen Bjørn, Arisa Tobi, Umadevi Deivasigamani, Dalton Hannah L, Hawes Chris S, Estalayo-Adrián Sandra, Savyasachi Aramballi J, Watson Graeme W, Williams D Clive, Gunnlaugsson Thorfinnur
机构信息
School of Chemistry and Trinity Biomedical Sciences Institute (TBSI), Trinity College Dublin, The University of Dublin, Dublin 2, Ireland.
出版信息
Chem Commun (Camb). 2018 Apr 19;54(33):4120-4123. doi: 10.1039/c8cc01584h.
The synthesis, photophysics and biological investigation of fluorescent 4-amino-1,8-naphthalimide Tröger's bases (TB-1-TB-3) and a new Tröger's base p-cymene-Ru(ii)-curcumin organometallic conjugate (TB-Ru-Cur) are described; these compounds showed fast cellular uptake and displayed good luminescence and cytotoxicity against cervical cancer cells.
描述了荧光4-氨基-1,8-萘二甲酰亚胺Tröger碱（TB-1-TB-3）和一种新型Tröger碱对伞花烃-Ru（II）-姜黄素有机金属共轭物（TB-Ru-Cur）的合成、光物理性质及生物学研究；这些化合物显示出快速的细胞摄取，并对宫颈癌细胞表现出良好的发光性能和细胞毒性。
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