Department of Psychology, Saint Louis University, St. Louis, MO, United States.
Warren Alpert Medical School, Brown University, Providence, RI, United States.
Curr Alzheimer Res. 2018;15(9):820-827. doi: 10.2174/1567205015666180404170359.
There exists a need for more sensitive measures capable of detecting subtle cognitive decline due to Alzheimer's disease.
To advance the literature in Alzheimer's disease by demonstrating that performance on a cued-Stroop task is impacted by preclinical Alzheimer's disease neuropathology.
Twenty-nine cognitively asymptomatic older adults completed a computerized, cued-Stroop task in which accuracy rates and intraindividual variability in reaction times were the outcomes of interest. Cerebrospinal fluid biomarkers of Aβ42 and tau were measured and participants were then grouped according to a published p-tau/Aβ42 cutoff reflecting risk for Alzheimer's disease (preclinical Alzheimer's disease = 14; control = 15).
ANOVAs indicated that accuracy rates did not differ between the groups but 4-second delay incongruent color-naming Stroop coefficient of variation reaction times were higher in the preclinical Alzheimer's disease group compared to the control group, reflecting increased within-person variability. Moreover, partial correlations showed no relationships between cerebrospinal fluid biomarkers and accuracy rates. However, increases in coefficient of variation reaction times correlated with decreased Aβ42 and increases in p-tau and the p-tau/Aβ42 ratio.
Results supported the ability of the computerized, cued-Stroop task to detect subtle Alzheimer's disease neuropathology using a small cohort of cognitively asymptomatic older adults. The ongoing measurement of cued-Stroop coefficient of variation reaction times has both scientific and clinical utility in preclinical Alzheimer's disease.
由于阿尔茨海默病，需要更敏感的措施来检测微妙的认知能力下降。
通过证明在提示性 Stroop 任务中的表现受到阿尔茨海默病神经病理学的影响，来推进阿尔茨海默病领域的文献。
29 名认知无症状的老年人完成了一项计算机化的提示性 Stroop 任务，其准确性和反应时的个体内变异性是感兴趣的结果。测量了脑脊液中 Aβ42 和 tau 的生物标志物，然后根据反映阿尔茨海默病风险的发表的 p-tau/Aβ42 截止值将参与者分组（临床前阿尔茨海默病=14；对照组=15）。
方差分析表明，两组之间的准确率没有差异，但在临床前阿尔茨海默病组中，4 秒延迟不一致颜色命名 Stroop 变异系数的反应时间高于对照组，反映出个体内变异性增加。此外，偏相关表明脑脊液生物标志物与准确率之间没有关系。然而，变异系数反应时间的增加与 Aβ42 的减少以及 p-tau 和 p-tau/Aβ42 比值的增加相关。
结果支持使用一小部分认知无症状的老年人，计算机化提示性 Stroop 任务检测微妙的阿尔茨海默病神经病理学的能力。在临床前阿尔茨海默病中，持续测量提示性 Stroop 变异系数反应时间具有科学和临床应用价值。
