Nistor Marius, Schmidt Martin, Schiffner René
Department of Neurology, Jena University Hospital, Friedrich Schiller University, Jena, Germany.
Institute for Biochemistry II, Jena University Hospital, Friedrich Schiller University, Jena, Germany.
Neural Regen Res. 2018 Mar;13(3):402-405. doi: 10.4103/1673-5374.228713.
Since its discovery in the 1920's the relaxin peptide hormone family has not only grown in number to now seven members (relaxin-1, relaxin-2, relaxin-3, insulin-like peptide (INSL) 3, INSL4, INSL5 and INSL6), but ever more effects, suchs as vasodilatory, angiogenic, anti-apoptopic, anti-fibriotic and anti-inflammatory, have been linked to them. While relaxin-2 has mainly been investigated in the context of cardiac protection, most comprehensively in the RELAX-AHF and RELAX AHF2 studies, a small number of studies have furthermore assessed the potential neuroprotective effects of especially relaxin-2 and other members of the relaxin family. In this short review we summarise and discuss recent efforts to utilize relaxin hormones for neuroprotection and point out potential future fields of research and translational applications. While many questions still need to be answered, the promising results of the available studies definitely warrant future well-designed studies on neuroprotection by relaxin peptides.
自20世纪20年代被发现以来，松弛素肽激素家族不仅在数量上已发展到目前的七个成员（松弛素-1、松弛素-2、松弛素-3、胰岛素样肽（INSL）3、INSL4、INSL5和INSL6），而且越来越多的效应，如血管舒张、血管生成、抗凋亡、抗纤维化和抗炎等，都与它们相关联。虽然松弛素-2主要是在心脏保护的背景下进行研究，在RELAX-AHF和RELAX AHF2研究中最为全面，但少数研究还进一步评估了特别是松弛素-2和松弛素家族其他成员的潜在神经保护作用。在这篇简短的综述中，我们总结并讨论了利用松弛素激素进行神经保护的最新研究成果，并指出了潜在的未来研究领域和转化应用。虽然仍有许多问题需要解答，但现有研究的 promising 结果无疑值得未来开展关于松弛素肽神经保护的精心设计的研究。 （注：原文中“promising”未翻译完整，可能是输入有误，推测完整单词为“promising”，意为“有希望的、前景好的” ）
