Department of Chemistry , University of Texas at San Antonio , San Antonio , Texas 78249 , United States.
Org Lett. 2018 Apr 20;20(8):2472-2476. doi: 10.1021/acs.orglett.8b00836. Epub 2018 Apr 6.
Highly stereoselective 2-oxonia-Cope rearrangement reactions between newly designed bisvinylogous aldolation synthons and aldehydes, which can provide ε-hydroxy-α,β,γ,δ-unsaturated esters with excellent enantioselectivities, as well as with unprecedented E- and Z-selectivities without regioselectivity issues, are described.
描述了新设计的双乙烯基同多醇缩合试剂与醛之间高度立体选择性的 2-氧杂诺卡酮 Cope 重排反应，该反应可以提供具有优异对映选择性的 ε-羟基-α，β，γ，δ-不饱和酯，以及前所未有的 E 和 Z 选择性，而没有区域选择性问题。
