Canales Juan, Rada Gabriel
Facultad de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile; Proyecto Epistemonikos, Santiago, Chile.
Proyecto Epistemonikos, Santiago, Chile; Departamento de Medicina Interna, Facultad de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile; Centro Evidencia UC, Pontificia Universidad Católica de Chile, Santiago, Chile; GRADE working group; The Cochran Collaboration. Email:
Medwave. 2018 Apr 4;18(2):e7186. doi: 10.5867/medwave.2018.02.7185.
Urinary tract infection is the most common bacterial infection and recurrences are common. Probiotics have been proposed as an alternative to decrease this risk. However, it is not clear if they are really effective.
To answer this question we used Epistemonikos, the largest database of systematic reviews in health, which is maintained by screening multiple information sources, including MEDLINE, EMBASE, Cochrane, among others. We extracted data from the systematic reviews, reanalyzed data of primary studies, conducted a meta-analysis and generated a summary of findings table using the GRADE approach.
We identified six systematic reviews including nine studies overall, of which seven were randomized trials. We concluded it is not clear whether probiotics decrease the risk of symptomatic urinary tract infection, because the certainty of the evidence is very low.
尿路感染是最常见的细菌感染，且复发很常见。已有人提出使用益生菌作为降低这种风险的一种替代方法。然而，它们是否真的有效尚不清楚。
为回答这个问题，我们使用了Epistemonikos，这是健康领域最大的系统评价数据库，通过筛选多个信息来源进行维护，包括MEDLINE、EMBASE、Cochrane等。我们从系统评价中提取数据，重新分析了原始研究的数据，进行了荟萃分析，并使用GRADE方法生成了结果总结表。
我们确定了六项系统评价，总共包括九项研究，其中七项为随机试验。我们得出结论，由于证据的确定性非常低，尚不清楚益生菌是否能降低有症状尿路感染的风险。
