Photocatalytic Deuteration of Halides Using D O over CdSe Porous Nanosheets: A Mild and Controllable Route to Deuterated Molecules.

A facile and efficient method for deuterium incorporation has been developed by merging photocatalytic C-X bond dissociation and water splitting with porous CdSe nanosheets as the photocatalyst under mild reaction conditions. This reaction displays good functional group tolerance and high selectivity with regard to the number and position of incorporated deuterium atoms, and can be used for the construction of complex molecules in tandem processes.