Olga Tennison Autism Research Centre, School of Psychology and Public Health, La Trobe University, Bundoora, Victoria, Australia.
Department of Medicine, Austin Health, The University of Melbourne, Heidelberg, Victoria, Australia.
Autism Res. 2018 Jun;11(6):846-856. doi: 10.1002/aur.1952. Epub 2018 Apr 6.
Recent findings suggest that children with Autism Spectrum Disorder (ASD) are larger in size for head circumference (HC), height, and weight compared to typically developing (TD) children; however, little is known about their rate of growth, especially in height and weight. The current study aimed to: (a) confirm and extend upon previous findings of early generalized overgrowth in ASD; and (b) determine if there were any differences in the rate of growth between infants and toddlers with ASD compared to their TD peers. Measurements of HC, height, and weight were available for 135 boys with ASD and 74 TD boys, from birth through 3 years of age. Size and growth rate in HC, height, and weight were analyzed using a linear mixed-effects model. Infants with ASD were significantly smaller in size at birth for HC, body length, and weight compared to TD infants (all P < 0.05); however, they grew at a significantly faster rate in HC and height in comparison to the TD children (P < 0.001); there was no significant difference between the groups in growth rate for weight (P > 0.05). The results confirmed that male infants and toddlers with ASD exhibit skeletal growth dysregulation early in life. Autism Res 2018, 11: 846-856. © 2018 International Society for Autism Research, Wiley Periodicals, Inc.
Recent findings suggest that infants with Autism Spectrum Disorder (ASD) are smaller in size at birth compared to typically developing infants but grow larger than their peers during the first year. Little is known about their rate of growth, especially for height and weight. Our findings confirmed that infants with ASD are smaller in size at birth for head circumference (HC), height, and weight, but grow at a faster rate in HC and height than their peers from birth to 3 years.
（a）证实并扩展先前关于自闭症谱系障碍（ASD）儿童头围（HC）、身高和体重早期普遍过度生长的发现；（b）确定 ASD 婴儿和幼儿与 TD 同龄人相比，其生长速度在身高和体重方面是否存在差异。方法：对 135 名 ASD 男孩和 74 名 TD 男孩从出生到 3 岁的 HC、身高和体重进行了测量。使用线性混合效应模型分析了 HC、身高和体重的大小和生长速度。结果：ASD 婴儿出生时 HC、体长度和体重明显小于 TD 婴儿（均 P<0.05）；然而，与 TD 儿童相比，他们的 HC 和身高生长速度明显更快（P<0.001）；两组间体重生长速度无显著差异（P>0.05）。结论：ASD 男婴和幼儿在生命早期表现出骨骼生长失调。自闭症研究 2018, 11: 846-856. © 2018 自闭症国际研究协会，威利期刊，公司。
