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Type I IGF receptors of Leydig cells are upregulated by human chorionic gonadotropin.

作者信息

Lin T, Blaisdell J, Haskell J F

机构信息

Medical Service, WJB Dorn Veterans' Hospital, Columbia, South Carolina.

出版信息

Biochem Biophys Res Commun. 1987 Dec 31;149(3):852-8. doi: 10.1016/0006-291x(87)90486-4.

DOI:10.1016/0006-291x(87)90486-4
PMID:2962579
Abstract

The effects of human chorionic gonadotropin (hCG) on type I insulin-like growth factor (IGF) receptors of purified Leydig cells were investigated. Sprague-Dawley rats (50 day-old) were treated with a single injection of hCG 10 units intraperitoneally, type I IGF receptors were then determined daily for 4 days. HCG caused a rapid increase in type I IGF receptors within 24 h, which returned to basal by 72 h. There was no significant change in binding affinity. Our present study indicates that type I IGF receptors of Leydig cells are up regulated by hCG, and this may be one mechanism by which hCG and IGF-I interact to enhance Leydig cell steroidogenesis.

摘要

相似文献

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Type I IGF receptors of Leydig cells are upregulated by human chorionic gonadotropin.
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