人类衰竭心脏中β-人心房利钠多肽的合成增加。

Augmented synthesis of beta-human atrial natriuretic polypeptide in human failing hearts.

作者信息

Sugawara A, Nakao K, Morii N, Yamada T, Itoh H, Shiono S, Saito Y, Mukoyama M, Arai H, Nishimura K

机构信息

Department of Medicine, Kyoto University School of Medicine, Japan.

出版信息

Biochem Biophys Res Commun. 1988 Jan 15;150(1):60-7. doi: 10.1016/0006-291x(88)90486-x.

DOI:10.1016/0006-291x(88)90486-x

PMID:2962584

Abstract

To elucidate the synthesis of atrial natriuretic polypeptide (ANP) in the failing heart, eighteen human right auricles obtained at cardiovascular surgery were studied. The concentration of alpha-human ANP-like immunoreactivity (alpha-hANP-LI) in human right auricles ranged from 13.8 to 593.5 micrograms/g, and the tissue alpha-hANP-LI concentration in severe congestive heart failure (CHF) (New York Heart Association (NYHA) functional class III or IV) was much higher than those in mild CHF of NYHA class I and class II. The alpha-hANP-LI in the human auricle consisted of 3 major components of ANP, gamma-human ANP (gamma-hANP), beta-human ANP (beta-hANP) and alpha-human ANP (alpha-hANP). The predominant component of alpha-hANP-LI was gamma-hANP in the mild CHF, whereas beta-hANP and/or alpha-hANP were prevailing in the severe CHF and, especially, beta-hANP was markedly increased in human failing hearts.

摘要

为阐明衰竭心脏中的心钠素（ANP）合成情况，对心血管手术中获取的18例人右心耳进行了研究。人右心耳中α-人ANP样免疫反应性（α-hANP-LI）的浓度范围为13.8至593.5微克/克，重度充血性心力衰竭（CHF）（纽约心脏协会（NYHA）功能分级III或IV级）时组织α-hANP-LI浓度远高于NYHA I级和II级的轻度CHF。人耳中的α-hANP-LI由ANP的3种主要成分组成，即γ-人ANP（γ-hANP）、β-人ANP（β-hANP）和α-人ANP（α-hANP）。轻度CHF时α-hANP-LI的主要成分是γ-hANP，而重度CHF时β-hANP和/或α-hANP占主导，尤其是β-hANP在人衰竭心脏中显著增加。