碘 123 标记依替唑仑单光子发射计算机断层扫描测定γ-氨基丁酸 A 受体成熟变化与苯二氮䓬结合。

Maturational Changes of Gamma-Aminobutyric Acid A Receptors Measured With Benzodiazepine Binding of Iodine 123 Iomazenil Single-Photon Emission Computed Tomography.

机构信息

Division of Neurology, Saitama Children's Medical Center, Saitama, Japan; Department of Pediatrics, Jikei University School of Medicine, Tokyo, Japan.

Division of Neurology, Saitama Children's Medical Center, Saitama, Japan; Department for Child Health and Human Development, Saitama Children's Medical Center, Saitama, Japan.

出版信息

Pediatr Neurol. 2018 May;82:19-24. doi: 10.1016/j.pediatrneurol.2018.02.008. Epub 2018 Apr 3.

DOI:10.1016/j.pediatrneurol.2018.02.008

PMID:29625846

Abstract

BACKGROUND

Iodine 123 (I-123) iomazenil is a specific ligand of the central benzodiazepine receptor, which is a part of the postsynaptic gamma-aminobutyric acid A receptor complex. We performed statistical image processing of I-123 iomazenil single-photon emission computed tomography to elucidate maturational changes in the GABAergic system.

METHODS

Thirty patients (18 boys and 12 girls, aged 17 days to 14 years) with cryptogenic focal epilepsy were enrolled and underwent I-123 iomazenil single-photon emission computed tomography. We used a semiquantitative analytical method consisting of brain surface extraction, anatomic normalization, and a three-parameter exponential model. We then assessed developmental changes in benzodiazepine receptor binding activity in 18 regions of interest in both hemispheres.

RESULTS

The highest benzodiazepine receptor binding activity was observed during early infancy in all regions of interest. Benzodiazepine receptor binding activity then decreased exponentially across development. Benzodiazepine receptor binding in the primary sensorimotor cortex, primary visual cortex, cerebellar vermis, and striatum declined more rapidly than that in the cerebellar hemispheres and the frontal cortex. The pons and the thalamus had the lowest benzodiazepine receptor binding activities during the neonatal period, and benzodiazepine receptor binding in these areas declined gradually after infancy toward adolescence. There were no differences in adjusted benzodiazepine receptor binding activity according to laterality or sex.

CONCLUSIONS

Benzodiazepine receptor binding activity decreased exponentially during infancy in all regions of interest. Binding activity in the primary somatosensory and motor cortices (M1 and S1), the primary and association visual areas, the cerebellar vermis, and the striatum (caudate nucleus and putamen) tended to decline more rapidly than that in the cerebellar hemisphere and the frontal association cortex.

摘要

背景

碘 123（I-123）依马唑仑是中枢苯二氮䓬受体的特异性配体，后者是突触后γ-氨基丁酸 A 受体复合物的一部分。我们对 I-123 依马唑仑单光子发射计算机断层扫描进行了统计图像处理，以阐明 GABA 能系统的成熟变化。

方法

我们招募了 30 名（18 名男孩和 12 名女孩，年龄 17 天至 14 岁）患有隐源性局灶性癫痫的患者，并进行了 I-123 依马唑仑单光子发射计算机断层扫描。我们使用了一种半定量分析方法，包括脑表面提取、解剖归一化和三参数指数模型。然后，我们评估了 18 个感兴趣区域的苯二氮䓬受体结合活性在两个半球的发育变化。

结果

在所有感兴趣区域，苯二氮䓬受体结合活性在婴儿早期最高。随后，苯二氮䓬受体结合活性在发育过程中呈指数下降。初级感觉运动皮层、初级视觉皮层、小脑蚓部和纹状体的苯二氮䓬受体结合活性下降速度快于小脑半球和额叶的苯二氮䓬受体结合活性。桥脑和丘脑在新生儿期具有最低的苯二氮䓬受体结合活性，这些区域的苯二氮䓬受体结合活性在婴儿期后逐渐下降至青春期。根据侧别或性别，调整后的苯二氮䓬受体结合活性没有差异。