Smith S D, Morgan R, Gemmell R, Amylon M D, Link M P, Linker C, Hecht B K, Warnke R, Glader B E, Hecht F
Department of Pediatrics and Pathology, Stanford University School of Medicine, CA.
Blood. 1988 Feb;71(2):395-402.
In T cell malignancy, rearrangements of chromosome 14 have been observed with a break in the band that contains the alpha chain gene for the T cell receptor (TCR). Because the beta chain TCR gene is in chromosome band 7q34, we searched for and report finding specific rearrangements of 7q34 exclusively in T cell malignancies. The rearrangements were reciprocal translocations between 7q34 and other points: 1p34, 9q32, 9q34, 15q22, and 19p13. The malignancies containing a 7q34 translocation were either T cell acute lymphoblastic leukemias or T cell lymphoblastic lymphomas that had similarities in clinical, enzyme, immunologic, and cellular characteristics. Hybridization using a probe to the beta-TCR gene disclosed unique rearrangements consistent with clonality in every case. A common pattern with chromosome breakpoints involving TCR genes may be emerging in T cell neoplasia.
在T细胞恶性肿瘤中，已观察到14号染色体重排，其断裂发生在包含T细胞受体（TCR）α链基因的条带中。由于β链TCR基因位于7号染色体带7q34，我们进行了搜索并报告发现仅在T细胞恶性肿瘤中存在7q34的特定重排。这些重排是7q34与其他位点之间的相互易位：1p34、9q32、9q34、15q22和19p13。含有7q34易位的恶性肿瘤要么是T细胞急性淋巴细胞白血病，要么是T细胞淋巴母细胞淋巴瘤，它们在临床、酶学、免疫学和细胞特征方面具有相似性。使用β-TCR基因探针进行杂交显示，在每种情况下均存在与克隆性一致的独特重排。涉及TCR基因的染色体断点的常见模式可能正在T细胞肿瘤形成中出现。
