α受体阻滞剂在药物排石治疗中的作用是什么？对60项随机试验和9500多名患者的荟萃分析结果
What Is the Role of α-Blockers for Medical Expulsive Therapy? Results From a Meta-analysis of 60 Randomized Trials and Over 9500 Patients.
作者信息
Aboumarzouk Omar M, Jones Patrick, Amer Tarik, Kotsiris Dimitris, Emiliani Esteban, Somani Bhaskar, Kallidonis Panagiotis, Tailly Thomas, Atis Gohkan, Greco Francesco, Hruby Stephan, Alvarez Mario, Al-Rumaihi Khalid, Shamsodini Ahmad, Al-Ansari Abdulla, Shokeir Ahmed
机构信息
Glasgow Urological Research Unit, Department of Urology, Queen Elizabeth University Hospital, Glasgow, United Kingdom; School of Medicine, Dentistry and Nursing, University of Glasgow, Glasgow, United Kingdom; College of Medicine, Islamic Universities of Gaza, Gaza, Palestine; Young Academic Urologists Urolithiasis and Endourology Group of the European Association of Urology, Southampton, United Kingdom.
Young Academic Urologists Urolithiasis and Endourology Group of the European Association of Urology, Southampton, United Kingdom.
出版信息
Urology. 2018 Sep;119:5-16. doi: 10.1016/j.urology.2018.03.028. Epub 2018 Apr 4.
Use of α-blockers for medical expulsive therapy (MET) has been the subject of huge debate in urology. Moreover, there have been a number of randomized controlled trials with differing results. We conducted a systematic review and meta-analysis of randomized controlled trials investigating the efficacy of α-blockers for MET. This review confirms there is a role for α-blockers in MET for ureteric stones specifically in stones >5 mm and distal ureteric stones, which is associated with improved stone expulsion. However, there is a slight increase in risk of nonsignificant side effects.
在泌尿外科领域，使用α受体阻滞剂进行药物排石治疗（MET）一直是激烈争论的话题。此外，已经有多项随机对照试验，结果各不相同。我们对调查α受体阻滞剂用于MET疗效的随机对照试验进行了系统评价和荟萃分析。该评价证实，α受体阻滞剂在输尿管结石的MET中具有作用，特别是对于直径>5毫米的结石和输尿管下段结石，这与结石排出改善有关。然而，出现无显著意义副作用的风险略有增加。
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