Hip Injury and Disease Center, Henan Provincial Luoyang Orthopedic Hospital, Luoyang, 471002, China.
Department of Orthopedics, Longquan People's Hospital, Longquan, 323700, China.
Int J Surg. 2018 May;53:279-287. doi: 10.1016/j.ijsu.2018.03.078. Epub 2018 Apr 5.
This study aims to compare the efficacy of intra-articular injection of hyaluronic acid (HA) and platelet-rich plasma (PRP) for treating hip osteoarthritis (OA).
We performed systematic searches in PubMed, EmBase, ScienceDirect Web of science and the Cochrane Library for relevant literature published in or before February 2018. Only randomized controlled trials (RCTs) were included. The risk of bias assessment was performed using the tool recommended in the Cochrane Handbook for Systematic Reviews of Interventions (version 5.1.0). We used STATA 14.0 (College Station, TX, USA) to analyze the data.
A total of 287 records were identified by the initial database search. Finally, 4 RCTs were included in our study. The present meta-analysis indicated that PRP was associated with a significant reduction of VAS score at 2 months compared with HA. However, it did not show significantly better outcomes at 6 and 12 months. There was no significant difference regarding the WOMAC and HHS at a 12-month follow up. No increased risk of adverse effects were observed.
Intra-articular injection of PRP was associated with a significant reduction of VAS at 2 months. Both of them showed comparable results in terms of functional recovery. Further studies were still necessary.
本研究旨在比较关节内注射透明质酸（HA）和富含血小板的血浆（PRP）治疗髋骨关节炎（OA）的疗效。
我们在 PubMed、EmBase、ScienceDirect 网络科学和 Cochrane 图书馆中进行了系统检索，以查找截至 2018 年 2 月发表的相关文献。仅纳入随机对照试验（RCT）。使用 Cochrane 干预系统评价手册（版本 5.1.0）中推荐的工具进行偏倚风险评估。我们使用 STATA 14.0（美国德克萨斯州学院站）进行数据分析。
通过初始数据库搜索共确定了 287 条记录。最后，有 4 项 RCT 纳入本研究。本荟萃分析表明，与 HA 相比，PRP 在 2 个月时 VAS 评分显著降低。然而，在 6 个月和 12 个月时，其结果并没有明显改善。在 12 个月的随访中，WOMAC 和 HHS 没有显著差异。没有观察到不良反应风险增加。
关节内注射 PRP 可显著降低 2 个月时的 VAS。在功能恢复方面，两者的结果相当。仍需要进一步研究。
