Department of Anesthesiology, The First Affiliated Hospital, Wenzhou Medical University, Wenzhou, Zhejiang Province, China.
Department of Anesthesiology, Lishui Central Hospital, The Fifth Affiliated Hospital, Wenzhou Medical University, Lishui, Zhejiang Province, China.
Basic Clin Pharmacol Toxicol. 2018 Aug;123(2):202-206. doi: 10.1111/bcpt.13022. Epub 2018 May 28.
This prospective study evaluated the 95% effective dose (ED ) of nalbuphine in inhibiting body movement during outpatient-induced abortion and its clinical efficacy versus the equivalent of sufentanil. The study was divided into two parts. For the first part, voluntary first-trimester patients who needed induced abortions were recruited to measure the ED of nalbuphine in inhibiting body movement during induced abortion using the sequential method (the Dixon up-and-down method). In the second part, this was a double-blind, randomized study. Sixty cases of first-trimester patients were recruited and were randomly divided into two groups (n = 30), including group N (nalbuphine at the ED dose) and group S (sufentanil at an equivalent dose). Propofol was given to both groups as the sedative. The circulation, respiration and body movement of the two groups in surgery were observed. The amount of propofol, the awakening time, the time to leave the hospital and the analgesic effect were recorded. The ED of nalbuphine in inhibiting body movement during painless surgical abortion was 0.128 mg/kg (95% confidence intervals 0.098-0.483 mg/kg). Both nalbuphine and the equivalent dose of sufentanil provided a good intraoperative and post-operative analgesic effect in outpatient-induced abortion. However, the post-operative morbidity of dizziness for nalbuphine was less than for sufentanil (p < 0.05), and the awakening time and the time to leave the hospital were significantly shorter than those of sufentanil (p < 0.05). Nalbuphine at 0.128 mg/kg was used in outpatient-induced abortion as an intraoperative and post-operative analgesic and showed a better effect compared with sufentanil.
本前瞻性研究评估了纳布啡在抑制门诊人工流产中躯体运动的 95%有效剂量（ED）及其与等效舒芬太尼的临床疗效。该研究分为两部分。第一部分，招募需要人工流产的自愿性初孕妇，采用序贯法（Dixon 上下法）测量纳布啡抑制人工流产中躯体运动的 ED。第二部分，这是一项双盲、随机研究。共招募 60 例初孕妇，随机分为两组（n=30），包括 N 组（纳布啡 ED 剂量）和 S 组（等效舒芬太尼剂量）。两组均给予丙泊酚作为镇静剂。观察两组手术中的循环、呼吸和躯体运动，记录两组丙泊酚用量、苏醒时间、离院时间和镇痛效果。无痛人工流产中抑制躯体运动的纳布啡 ED 为 0.128mg/kg（95%置信区间 0.098-0.483mg/kg）。纳布啡和等效舒芬太尼均能为门诊人工流产提供良好的术中及术后镇痛效果，但纳布啡术后头晕发生率低于舒芬太尼（p<0.05），苏醒时间和离院时间明显短于舒芬太尼（p<0.05）。纳布啡 0.128mg/kg 用于门诊人工流产作为术中及术后镇痛，效果优于舒芬太尼。
