Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, Milan, Italy.
Vascular Surgery Unit Department of Translational Research and Advanced Technologies in Medicine, University of Pisa, Pisa, Italy.
Semin Nucl Med. 2018 May;48(3):225-241. doi: 10.1053/j.semnuclmed.2018.02.003.
Hybrid positron emission tomography/magnetic resonance imaging (PET/MR) systems are now more and more available for clinical use. PET/MR combines the unique features of MR including excellent soft tissue contrast, diffusion-weighted imaging, dynamic contrast-enhanced imaging, fMRI and other specialized sequences as well as MR spectroscopy with the quantitative physiologic information that is provided by PET. Most of the evidence of the potential clinical utility of PET/MRI is available for neuroimaging. Other areas, where PET/MR can play a larger role include head and neck, upper abdominal, and pelvic tumours. Although the role of PET/MR in infection and inflammation of the cardiovascular system and in musculoskeletal applications are promising, these areas of clinical investigation are still in the early phase and it may be a little longer before these areas reach their full potential in clinical practice. In this review, we outline the potential of hybrid PET/MR for imaging infection and inflammation. A background to the main radiopharmaceuticals and some technical considerations are also included.
混合正电子发射断层扫描/磁共振成像（PET/MR）系统现在越来越多地可用于临床应用。PET/MR 结合了磁共振的独特功能，包括出色的软组织对比度、扩散加权成像、动态对比增强成像、功能磁共振成像和其他专门序列以及磁共振波谱，同时提供了由 PET 提供的定量生理信息。PET/MRI 的潜在临床应用的大部分证据都可用于神经影像学。其他领域，如头颈部、上腹部和盆腔肿瘤，PET/MR 也可以发挥更大的作用。尽管 PET/MR 在心血管系统感染和炎症以及肌肉骨骼应用中的作用很有前景，但这些临床研究领域仍处于早期阶段，在这些领域在临床实践中充分发挥潜力之前，可能还需要一段时间。在这篇综述中，我们概述了混合 PET/MR 在感染和炎症成像中的潜力。本文还介绍了主要放射性药物的背景和一些技术考虑因素。
