Russell H. Morgan Department of Radiology and Radiological Sciences, Johns Hopkins University School of Medicine, Baltimore, MD; Center for Infection and Inflammation Imaging Research, Johns Hopkins University School of Medicine, Baltimore, MD.
Center for Infection and Inflammation Imaging Research, Johns Hopkins University School of Medicine, Baltimore, MD; Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, MD.
Semin Nucl Med. 2018 May;48(3):242-245. doi: 10.1053/j.semnuclmed.2017.12.002. Epub 2018 Feb 13.
Macrophages belong to the mononuclear phagocyte system comprising closely related cells of bone marrow origin. Activated macrophages are critical in several diseases such as tuberculosis, sarcoidosis, Crohn's disease, and atherosclerosis. Noninvasive imaging techniques that can specifically image activated macrophages could therefore help in differentiating various forms of inflammatory diseases and to monitor therapeutic responses.
巨噬细胞属于单核吞噬细胞系统，由骨髓来源的密切相关的细胞组成。活化的巨噬细胞在几种疾病中起关键作用，如结核病、结节病、克罗恩病和动脉粥样硬化。因此，能够特异性地成像活化的巨噬细胞的非侵入性成像技术有助于区分各种形式的炎症性疾病，并监测治疗反应。
