吡唑并[3,4-d]嘧啶骨架的合成与临床方面的新进展。
New advances in synthesis and clinical aspects of pyrazolo[3,4-d]pyrimidine scaffolds.
机构信息
Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Beni-Suef University, Beni-Suef 62514, Egypt; Pharmaceutical Sciences Department, Ibn Sina National College for Medical Studies, Jeddah 21418, Saudi Arabia.
Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Beni-Suef University, Beni-Suef 62514, Egypt; Department of Pharmaceutical Chemistry, College of Pharmacy, Jouf University, Sakaka, Al Jouf 2014, Saudi Arabia.
出版信息
Bioorg Chem. 2018 Aug;78:341-357. doi: 10.1016/j.bioorg.2018.03.032. Epub 2018 Apr 3.
Pyrazolo[3,4-d]pyrimidine ring system constitute an important class of heterocyclic compounds which can serve as a promising scaffold exhibiting many pharmacological activities. This ring system received much attention as it is a purine isostere by replacing imidazole ring in purine with pyrazole moiety in pyrazolo[3,4-d]pyrimidine. Here we concentrate on new advances in the synthesis of this important ring and other clinical aspects in an attempt to sheld the light to assist in discovery of new pyrazolo[3,4-d]pyrimidine derivatives.
吡唑并[3,4-d]嘧啶环系统是一类重要的杂环化合物，可用作展示多种药理活性的有前途的支架。该环系统受到广泛关注，因为它是嘌呤的等排体，用吡唑取代嘌呤中的咪唑环形成吡唑并[3,4-d]嘧啶。本文主要集中讨论该重要环的合成新进展及其他临床方面的进展，旨在为发现新的吡唑并[3,4-d]嘧啶衍生物提供帮助。
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