Service de médecine interne et rhumatologie, unité d'infectiologie, hôpitaux civils de Colmar, 39, avenue de la Liberté, 68024 Colmar, France.
Service de médecine interne et rhumatologie, unité d'infectiologie, hôpitaux civils de Colmar, 39, avenue de la Liberté, 68024 Colmar, France.
Med Mal Infect. 2018 Jun;48(4):286-290. doi: 10.1016/j.medmal.2018.03.002. Epub 2018 Apr 5.
Cerebrospinal fluid (CSF) leukocytes analysis is commonly used to diagnose meningitis and to differentiate bacterial from viral meningitis. Interpreting CSF monocytes can be difficult for physicians, especially in France where lymphocytes and monocytes results are sometimes pooled.
We assessed SF monocytes in patients presenting with microbiologically confirmed meningitis (CSF leukocyte count>10/mm for adults or >30/mm for children<2 months), i.e. bacterial meningitis (BM), viral meningitis (VM), and neuroborreliosis (NB).
Two-hundred patients (82 BM, 86 VM, and 32 NB) were included. The proportions of monocytes were higher in VM (median 8%; range 0-57%) than in BM (median 5%; range 0-60%, P=0.03) or NB (median 5%; range 0-53%, P=0.46), with a high value overlap between conditions.
CSF monocytes should not be used to discriminate BM from VM and NB because of value overlaps.
脑脊液(CSF)白细胞分析通常用于诊断脑膜炎,并区分细菌性脑膜炎和病毒性脑膜炎。对于医生来说,解读 CSF 中的单核细胞可能具有一定难度,尤其是在法国,淋巴细胞和单核细胞的结果有时会被合并。
我们评估了患有微生物学确诊脑膜炎(成人 CSF 白细胞计数>10/mm,2 个月以下儿童>30/mm)的患者的 SF 单核细胞,包括细菌性脑膜炎(BM)、病毒性脑膜炎(VM)和神经莱姆病(NB)。
共纳入 200 例患者(82 例 BM、86 例 VM 和 32 例 NB)。VM 患者单核细胞的比例较高(中位数 8%;范围 0-57%),高于 BM(中位数 5%;范围 0-60%,P=0.03)或 NB(中位数 5%;范围 0-53%,P=0.46),各疾病之间存在较高的重叠值。
由于值重叠,CSF 单核细胞不能用于区分 BM 与 VM 和 NB。