Sano Michael B, Fan Richard E, Cheng Kai, Saenz Yamil, Sonn Geoffrey A, Hwang Gloria L, Xing Lei
Department of Radiation Oncology and Division of Radiation Physics, Stanford University Medical Center, Stanford, California; University of North Carolina/North Carolina State University Joint Department of Biomedical Engineering, 4130 Engineering Building III, Campus Box 7115, Raleigh, NC 27695.
Department of Urology, Stanford University Medical Center, Stanford, California.
J Vasc Interv Radiol. 2018 Jun;29(6):893-898.e4. doi: 10.1016/j.jvir.2017.12.019. Epub 2018 Apr 6.
To compare the intensity of muscle contractions in irreversible electroporation (IRE) treatments when traditional IRE and high-frequency IRE (H-FIRE) waveforms are used in combination with a single applicator and distal grounding pad (A+GP) configuration.
An ex vivo in situ porcine model was used to compare muscle contractions induced by traditional monopolar IRE waveforms vs high-frequency bipolar IRE waveforms. Pulses with voltages between 200 and 5,000 V were investigated, and muscle contractions were recorded by using accelerometers placed on or near the applicators.
H-FIRE waveforms reduced the intensity of muscle contractions in comparison with traditional monopolar IRE pulses. A high-energy burst of 2-μs alternating-polarity pulses energized for 200 μs at 4,500 V produced less intense muscle contractions than traditional IRE pulses, which were 25-100 μs in duration at 3,000 V.
H-FIRE appears to be an effective technique to mitigate the muscle contractions associated with traditional IRE pulses. This may enable the use of voltages greater than 3,000 V necessary for the creation of large ablations in vivo.
比较在使用单个电极和远端接地垫（A+GP）配置时，传统不可逆电穿孔（IRE）和高频IRE（H-FIRE）波形相结合用于IRE治疗时的肌肉收缩强度。
使用离体原位猪模型比较传统单极IRE波形与高频双极IRE波形诱导的肌肉收缩。研究了电压在200至5000V之间的脉冲，并通过放置在电极上或附近的加速度计记录肌肉收缩情况。
与传统单极IRE脉冲相比，H-FIRE波形降低了肌肉收缩强度。在4500V下持续200μs的2μs交替极性脉冲的高能脉冲串产生的肌肉收缩强度低于传统IRE脉冲，传统IRE脉冲在3000V下持续时间为25至100μs。
H-FIRE似乎是减轻与传统IRE脉冲相关的肌肉收缩的有效技术。这可能使得能够使用大于3000V的电压，而这对于在体内创建大的消融灶是必要的。
