Aboulnaga Sameh, Mahfouz Ahmed, Ewila Hesham A, Tuli Alejandro Kohn, Singh Rajvir, Omar Amr S, Al Khualifi Abdulaziz
Department of Cardiothoracic Surgery/Cardiac Anaesthesia and ICU Section, Heart Hospital, Hamad Medical Corporation, Qatar.
Department of Anesthesia, Ain Shams University, Cairo, Egypt.
Anesth Essays Res. 2018 Jan-Mar;12(1):223-228. doi: 10.4103/aer.AER_229_17.
Statin utilization had been associated with improved survival after cardiac surgery. We aim to study whether perioperative treatment with statin could be associated with increased postoperative complications.
This was a retrospective, descriptive, single-center study.
We analyzed morbidity after cardiac surgery as well as the outcome related to statin therapy in a tertiary cardiac center.
A total of 202 consecutive patients were enrolled over 1 year after cardiac surgery.
Patients were divided into two groups; Group I - statin users and Group II - nonusers.
Measurements were baseline and follow-up laboratory markers for muscular injury including cardiac muscle and hepatic injuries and renal injuries.
The incidence of rhabdomyolysis and elevation of liver enzymes did not differ between both groups. Postoperative atrial fibrillation was significantly lower in the statin group ( = 0.02). In addition, peak cardiac troponin and creatine kinase-MB did not differ significantly in the statin group. Statin-treated group had significant lower length of mechanical ventilation, and length of stay in the Intensive Care Unit and hospital ( = 0.036, 0.04, and 0.027, respectively).
Therapy with statin before cardiac surgeries was not associated with high incidence of adverse events.
他汀类药物的使用与心脏手术后生存率的提高有关。我们旨在研究围手术期使用他汀类药物是否会增加术后并发症。
这是一项回顾性、描述性、单中心研究。
我们在一家三级心脏中心分析了心脏手术后的发病率以及与他汀类药物治疗相关的结果。
心脏手术后1年内共纳入202例连续患者。
患者分为两组；第一组——他汀类药物使用者，第二组——非使用者。
测量指标为肌肉损伤（包括心肌、肝损伤和肾损伤）的基线和随访实验室指标。
两组间横纹肌溶解症和肝酶升高的发生率无差异。他汀类药物组术后房颤发生率显著较低（P = 0.02）。此外，他汀类药物组的心肌肌钙蛋白峰值和肌酸激酶同工酶无显著差异。他汀类药物治疗组的机械通气时间、重症监护病房住院时间和住院时间显著缩短（分别为P = 0.036、0.04和0.027）。
心脏手术前使用他汀类药物治疗与不良事件的高发生率无关。
