Shokouhi Shervin, Alavi Darazam Ilad, Sharifi Giv, Gachkar Latif, Amirsardari Anahita, Samadian Mohammad
Department of Infectious Disease, Loghman Hospital, Shahid Beheshti University of Medical Sciences, Tehran, IR Iran.
Department of Infectious Disease, Loghman Hospital, Shahid Beheshti University of Medical Sciences, Tehran, IR Iran ; National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, IR Iran.
Jundishapur J Microbiol. 2014 Apr;7(4):e9456. doi: 10.5812/jjm.9456. Epub 2014 Apr 1.
Observational studies, rather than randomized trials, revealed that statins might be associated with other benefits.
The present study aimed at evaluating the preventive effects of lovastatin when used as a prophylactic agent for early and late infective complications after surgery.
A total of 149 patients undergoing elective intracranial and spinal surgeries, were enrolled in a double- blind randomized clinical trial in the department of neurosurgery of a teaching hospital. An amount of 20 mg lovastatin and the same dose of placebo, one day before the operation and three days after the surgery, were used for cases and controls, respectively. The patients were evaluated for local and systemic infections during hospitalization and 10, 30, 60 and 90 days after discharge.
A total of 149 patients, 78 men and 71 women with a mean age of 40.3 ± 16.5, were assigned to prophylactic protocols. 46 and 103 patients were in the case and control groups, respectively. Eight episodes of infection were detected, including six bacterial meningitis and two episodes of hospital- acquired pneumonia. All of the patients with documented postoperative infections were part of the placebo group, however, there were no significant statistical differences between the groups (P = 0.059).
In spite of the differences between the two groups, the results did not significantly support the preventive effect of statins in postoperative infections.
观察性研究而非随机试验表明，他汀类药物可能具有其他益处。
本研究旨在评估洛伐他汀作为预防手术早期和晚期感染并发症的预防剂的预防效果。
在一家教学医院的神经外科进行了一项双盲随机临床试验，共纳入149例行择期颅内和脊柱手术的患者。分别对病例组和对照组在手术前一天和手术后三天使用20毫克洛伐他汀和相同剂量的安慰剂。在住院期间以及出院后10天、30天、60天和90天对患者进行局部和全身感染评估。
共有149例患者，78名男性和71名女性，平均年龄为40.3±16.5岁，被分配到预防方案组。病例组和对照组分别有46例和103例患者。检测到8例感染事件，包括6例细菌性脑膜炎和2例医院获得性肺炎。所有有术后感染记录的患者均为安慰剂组，但两组之间无显著统计学差异（P = 0.059）。
尽管两组之间存在差异，但结果并未显著支持他汀类药物对术后感染的预防作用。
