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具有泄漏、分布式和概率测量延迟的离散时间随机遗传调控网络状态变量的逼近:一个鲁棒稳定性问题。

Approximation of state variables for discrete-time stochastic genetic regulatory networks with leakage, distributed, and probabilistic measurement delays: a robust stability problem.

作者信息

Pandiselvi S, Raja R, Cao Jinde, Rajchakit G, Ahmad Bashir

机构信息

1Department of Mathematics, Alagappa University, Karaikudi, India.

2Ramanujan Centre for Higher Mathematics, Alagappa University, Karaikudi, India.

出版信息

Adv Differ Equ. 2018;2018(1):123. doi: 10.1186/s13662-018-1569-z. Epub 2018 Apr 3.

DOI:10.1186/s13662-018-1569-z
PMID:29628952
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5882887/
Abstract

This work predominantly labels the problem of approximation of state variables for discrete-time stochastic genetic regulatory networks with leakage, distributed, and probabilistic measurement delays. Here we design a linear estimator in such a way that the absorption of mRNA and protein can be approximated via known measurement outputs. By utilizing a Lyapunov-Krasovskii functional and some stochastic analysis execution, we obtain the stability formula of the estimation error systems in the structure of linear matrix inequalities under which the estimation error dynamics is robustly exponentially stable. Further, the obtained conditions (in the form of LMIs) can be effortlessly solved by some available software packages. Moreover, the specific expression of the desired estimator is also shown in the main section. Finally, two mathematical illustrative examples are accorded to show the advantage of the proposed conceptual results.

摘要

这项工作主要针对具有泄漏、分布式和概率测量延迟的离散时间随机遗传调控网络,标记了状态变量的近似问题。在此,我们设计了一种线性估计器,使得mRNA和蛋白质的吸收能够通过已知测量输出进行近似。通过利用李雅普诺夫 - 克拉索夫斯基泛函和一些随机分析方法,我们在线性矩阵不等式结构下获得了估计误差系统的稳定性公式,在该公式下估计误差动态是鲁棒指数稳定的。此外,所获得的条件(以线性矩阵不等式的形式)可以通过一些可用的软件包轻松求解。而且,所需估计器的具体表达式也在主要部分给出。最后,给出了两个数学示例以展示所提出概念结果的优势。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b189/5882887/f04e53934ae5/13662_2018_1569_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b189/5882887/50bfe086e453/13662_2018_1569_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b189/5882887/1091614ca57e/13662_2018_1569_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b189/5882887/f04e53934ae5/13662_2018_1569_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b189/5882887/50bfe086e453/13662_2018_1569_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b189/5882887/1091614ca57e/13662_2018_1569_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b189/5882887/f04e53934ae5/13662_2018_1569_Fig3_HTML.jpg

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本文引用的文献

1
Synchronization of Delayed Memristive Neural Networks: Robust Analysis Approach.时滞忆阻神经网络的同步:鲁棒分析方法。
IEEE Trans Cybern. 2016 Dec;46(12):3377-3387. doi: 10.1109/TCYB.2015.2505903. Epub 2015 Dec 22.
2
Stability of genetic regulatory networks based on switched systems and mixed time-delays.基于切换系统和混合时滞的基因调控网络稳定性
Math Biosci. 2016 Aug;278:94-9. doi: 10.1016/j.mbs.2016.06.004. Epub 2016 Jun 17.
3
Genetic oscillation deduced from Hopf bifurcation in a genetic regulatory network with delays.
从具有延迟的基因调控网络中的霍普夫分岔推导得出的基因振荡。
Math Biosci. 2008 Sep;215(1):55-63. doi: 10.1016/j.mbs.2008.05.004. Epub 2008 May 24.
4
Exponential stability of discrete-time genetic regulatory networks with delays.具有时滞的离散时间基因调控网络的指数稳定性
IEEE Trans Neural Netw. 2008 Mar;19(3):520-3. doi: 10.1109/TNN.2007.911748.