Kime D E, Larsen L O
Department of Zoology, University of Sheffield, United Kingdom.
Gen Comp Endocrinol. 1987 Nov;68(2):189-96. doi: 10.1016/0016-6480(87)90028-1.
Testosterone, estradiol, and dehydroepiandrosterone (T, E2, and DHA) were measured by RIA in plasma samples from three groups of sexually immature male and female (male, female) river lampreys: (I) intact, (II) gonadectomized, or (III) with pro- and mesoadenohypophysis removed (hypophysectomized). T levels were around 0.1 ng/ml in both I male and I female and increased significantly in all operated groups, especially in II male, to 1.2 ng/ml. E2 levels were between 0.7 and 1 ng/ml in I male and I female and were significantly elevated only in II male to 2.0 ng/ml. DHA levels showed significant decreases, from around 0.9 ng/ml in I male and I female, in both operated groups. It is suggested that T and E2 are secreted from a nongonadal source in both sexes and then converted to biologically active sex hormones in the gonads. Therefore T and E2 do not decrease, and may even accumulate, in the blood after gonadectomy. Since extirpation of the pro- and mesoadenohypophysis was not followed by a decrease in T and E2, their secretion may be stimulated by a hormone from another part of the pituitary such as the metaadenohypophysis.
采用放射免疫分析法（RIA）测定了三组性未成熟的雄性和雌性河鳗血浆样本中的睾酮、雌二醇和脱氢表雄酮（T、E2和DHA）：（I）完整组，（II）性腺切除组，或（III）切除前腺垂体和中腺垂体组（垂体切除组）。I组雄性和雌性的T水平均约为0.1 ng/ml，所有手术组的T水平均显著升高，尤其是II组雄性，升至1.2 ng/ml。I组雄性和雌性的E2水平在0.7至1 ng/ml之间，仅II组雄性显著升高至2.0 ng/ml。DHA水平在两个手术组中均显著下降，I组雄性和雌性中约为0.9 ng/ml。提示T和E2在两性中均由非性腺来源分泌，然后在性腺中转化为具有生物活性的性激素。因此，性腺切除后，T和E2在血液中不会减少，甚至可能会积累。由于切除前腺垂体和中腺垂体后T和E2并未下降，它们的分泌可能受到垂体其他部分如后腺垂体分泌的激素的刺激。
