Narang A P
Department of Hepatology, Postgraduate Institute of Medical Education and Research, Chandigarh.
Indian J Physiol Pharmacol. 1987 Jul-Sep;31(3):170-7.
Drugs are chiefly metabolised in the liver usually in two phases, viz. oxidation and conjugation. The present study was undertaken to investigate the effect of protein-calorie malnutrition (PCM), rehabilitation and effect of phenobarbitone on the hepatic drug metabolising enzymes in weanling albino rats, fed on a semisynthetic diet containing 18% or 0.5% protein. The two representative enzymes of oxidation and conjugation employed were aminopyrine N-demethylase and bilirubin UDP-glucuronyl transferase, respectively. The study revealed that PCM severely impairs oxidative drug metabolising enzyme but less so in conjugation stage. On refeeding 18% protein diet, drug metabolising enzymes returned to normal within 2-3 weeks. Phenobarbitone administration increased the activities of drug metabolising enzymes.
药物主要在肝脏中进行代谢，通常分为两个阶段，即氧化和结合。本研究旨在调查蛋白质 - 热量营养不良（PCM）、康复以及苯巴比妥对断奶白化大鼠肝脏药物代谢酶的影响，这些大鼠喂食含18%或0.5%蛋白质的半合成饮食。所采用的氧化和结合的两种代表性酶分别是氨基比林N - 脱甲基酶和胆红素UDP - 葡萄糖醛酸基转移酶。研究表明，PCM严重损害氧化药物代谢酶，但对结合阶段的损害较小。重新喂食18%蛋白质饮食后，药物代谢酶在2 - 3周内恢复正常。给予苯巴比妥可增加药物代谢酶的活性。
