a Faculty of Pharmacy, Pharmacognosy Department , Helwan University , Cairo , Egypt.
b Pharmaceuticals and Medicinal Plants (Mepaco) , Enshas El Raml Sharkyah , Egypt.
Nat Prod Res. 2019 Sep;33(18):2714-2717. doi: 10.1080/14786419.2018.1460843. Epub 2018 Apr 9.
(Lamiaceae) essential oils composition and yield were found to be greatly influenced by water stress and growth enhancers. Therefore, three controlled cultivation conditions were applied to achieve the highest essential oil productivity of . The essential oils obtained by hydro-distillation of the aerial parts were analyzed using (GC-MS). The tested plant subjected to drought showed a 66% increase in the essential oil yield, while those subjected to drought stress and foliar spray showed 57.1% increase and the regularly irrigated group with foliar spraying showed 23.8% increase relative to the control group. The cytotoxic activity of essential oils was evaluated against lung (A-549), colon (HCT-116), intestinal (CACO) and breast (MCF-7) carcinoma using the cell viability assay. The lowest IC values 0.44 and 0.33 μg/mL were seen against (HCT-116) and (CACO) cells respectively. These IC values were lower than that of doxorubicin used as reference drug.
（唇形科）精油的组成和产量受水分胁迫和生长促进剂的影响很大。因此，采用了三种控制栽培条件来实现 的最高精油生产力。用水蒸气蒸馏法从地上部分提取的精油，用（GC-MS）进行了分析。干旱处理的受试植物精油产量增加了 66%，而干旱胁迫和叶面喷施的植物精油产量增加了 57.1%，定期灌溉并进行叶面喷施的植物精油产量比对照组增加了 23.8%。采用细胞活力测定法，评估了 精油对肺癌（A-549）、结肠癌（HCT-116）、肠道（CACO）和乳腺癌（MCF-7）癌细胞的细胞毒性活性。对（HCT-116）和（CACO）细胞的最低 IC 值分别为 0.44 和 0.33μg/mL。这些 IC 值低于用作参考药物的多柔比星。
