An Emerging Pathway of Doxorubicin Cardiotoxicity Mediated through CYP2J2.
作者信息
Arnold William R, Das Aditi
出版信息
Biochemistry. 2018 Apr 24;57(16):2294-2296. doi: 10.1021/acs.biochem.8b00337. Epub 2018 Apr 9.
Abstract
摘要
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2
The roles of CYP450 epoxygenases and metabolites, epoxyeicosatrienoic acids, in cardiovascular and malignant diseases.CYP450 加单氧酶环氧合酶及其代谢产物环氧二十碳三烯酸在心血管和恶性疾病中的作用。
Adv Drug Deliv Rev. 2011 Jul 18;63(8):597-609. doi: 10.1016/j.addr.2011.03.006. Epub 2011 Apr 6.
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Overexpression of CYP2J2 provides protection against doxorubicin-induced cardiotoxicity.CYP2J2的过表达可提供针对阿霉素诱导的心脏毒性的保护作用。
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J Mol Cell Cardiol. 2007 Mar;42(3):687-91. doi: 10.1016/j.yjmcc.2006.11.020. Epub 2007 Jan 10.
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