Sarah S. Farabi, PhD Division of Endocrinology, Metabolism and Diabetes, School of Medicine, University of Colorado Anschutz Medical Campus, Aurora. Laurie Quinn, PhD Department of Biobehavioral Health Science, College of Nursing, University of Illinois at Chicago. Shane Phillips, PhD Department of Physical Therapy, College of Applied Health Sciences, University of Illinois at Chicago. Dan Mihailescu, MD College of Medicine, Endocrinology, Diabetes & Metabolism, University of Illinois at Chicago. Chang Park, PhD Department of Biobehavioral Health Science, College of Nursing, University of Illinois at Chicago. Mohammed Ali, MD, PhD Department of Physical Therapy, College of Applied Health Sciences, University of Illinois at Chicago. Pamela Martyn-Nemeth, PhD Department of Biobehavioral Health Science, College of Nursing, University of Illinois at Chicago.
J Cardiovasc Nurs. 2018 Jul/Aug;33(4):E21-E25. doi: 10.1097/JCN.0000000000000485.
Elevated cardiovascular disease risk in people with type 1 diabetes (T1DM) is incompletely understood. Glycemic control, glycemic variability, and sleep quality and duration may relate to cardiovascular disease risk in this population via endothelial dysfunction.
The aim of this study was to examine relationships among glycemic control, glycemic variability, sleep quality and duration, and endothelial function in adults with T1DM.
Endothelial function was measured using flow-mediated dilation. Glycemic control and glycemic variability were measured using A1C and a continuous glucose monitor, respectively; sleep quality and duration were measured with the Pittsburgh Sleep Quality Index.
Twenty subjects were recruited. Reduced flow-mediated dilation and higher glucose levels were associated with poorer sleep quality (r = -0.51, P = .01; r = 0.52, P = .03). Subjects with shorter sleep duration had greater glycemic variability.
Endothelial dysfunction (a precursor to cardiovascular disease) relates to glycemic control, glycemic variability, and sleep quality in T1DM.
1 型糖尿病（T1DM）患者的心血管疾病风险升高，但目前仍不完全清楚其发病机制。血糖控制、血糖变异性以及睡眠质量和时长可能通过内皮功能障碍与该人群的心血管疾病风险相关。
本研究旨在探讨 T1DM 成人的血糖控制、血糖变异性、睡眠质量和时长与内皮功能之间的关系。
使用血流介导的扩张来测量内皮功能。使用 A1C 和连续血糖监测仪分别测量血糖控制和血糖变异性；使用匹兹堡睡眠质量指数测量睡眠质量和时长。
共招募了 20 名受试者。血流介导的扩张减少和血糖水平升高与睡眠质量较差相关（r = -0.51，P =.01；r = 0.52，P =.03）。睡眠时长较短的受试者血糖变异性更大。
内皮功能障碍（心血管疾病的前兆）与 T1DM 患者的血糖控制、血糖变异性和睡眠质量有关。
