Department of Hepatobiliary Surgery, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, China.
Eur Rev Med Pharmacol Sci. 2018 Mar;22(6):1653-1657. doi: 10.26355/eurrev_201803_14575.
Investigating the molecular signaling pathways using CD13 as a marker for Cancer Stem Cells (CSCs) in human liver cancer.
In the present study, liver carcinoma biopsies were obtained from the liver cancer patients, as well as healthy controls. Immunohistochemistry and Immunoblotting experiments were performed accordingly to conclude the data.
Immunohistochemistry along with immunoblot data showed the expression of Oct-4, STAT3 and interestingly Embryonic Liver Fodrin (ELF) in the CD13 positive liver cancer stem cells. Though embryonic liver fodrin (ELF) is a pro-differentiation protein, it was expressed in the CD13 positive liver cancer stem cells along with stem cell markers such as Oct-4 and STAT3.
Our finding concludes that an association of ELF expression was noted in liver cancer patients. Hence, ELF may have value as prognostic indicators and may facilitate the development of novel therapeutics for liver cancer.
以 CD13 作为肝癌肿瘤干细胞（CSCs）的标志物，研究其分子信号通路。
本研究中，我们从肝癌患者和健康对照者获取肝肿瘤活检组织。通过免疫组化和免疫印迹实验来分析数据。
免疫组化和免疫印迹数据表明，Oct-4、STAT3 和有趣的胚胎肝 fodrin（ELF）在 CD13 阳性肝癌干细胞中表达。尽管胚胎肝 fodrin（ELF）是一种促分化蛋白，但它与 Oct-4 和 STAT3 等干细胞标志物一起在 CD13 阳性肝癌干细胞中表达。
我们的研究结果表明，ELF 在肝癌患者中表达存在相关性。因此，ELF 可能具有作为预后标志物的价值，并可能有助于开发肝癌的新型治疗方法。
