精神病性抑郁和非精神病性抑郁中的安慰剂反应率。
Placebo response rates in psychotic and nonpsychotic depression.
作者信息
Spiker D G, Kupfer D J
机构信息
University of Pittsburgh School of Medicine, PA 15213.
出版信息
J Affect Disord. 1988 Jan-Feb;14(1):21-3. doi: 10.1016/0165-0327(88)90067-5.
The authors reanalyzed data from two earlier studies that used double-blind placebo-controlled formats to study the efficacy of amitriptyline. Using a 14-day drug-free 'wash-out' period, they found that the placebo response rates were 0% for psychotic depressives and 13.3% for nonpsychotic depressives. Amitriptyline was significantly superior to placebo for both psychotic (P less than or equal to 0.05) and nonpsychotic (P less than or equal to 0.05) depressed patients.
作者重新分析了两项早期研究的数据，这两项研究采用双盲安慰剂对照形式来研究阿米替林的疗效。通过为期14天的药物洗脱期，他们发现精神病性抑郁症患者的安慰剂反应率为0%，非精神病性抑郁症患者的安慰剂反应率为13.3%。对于精神病性抑郁症患者（P≤0.05）和非精神病性抑郁症患者（P≤0.05），阿米替林均显著优于安慰剂。
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