在普通医疗中对抑郁症患者进行的阿米替林双盲安慰剂对照试验。
Double-blind placebo-controlled trial of amitriptyline among depressed patients in general practice.
作者信息
Hollyman J A, Freeling P, Paykel E S, Bhat A, Sedgwick P
出版信息
J R Coll Gen Pract. 1988 Sep;38(314):393-7.
Abstract
Depressed patients in general practice were included in a double-blind placebo-controlled six-week trial of amitriptyline (median dose 125 mg). The patients were relatively mildly ill and satisfied diagnostic criteria for depression and treatment with antidepressants in routine practice. Amitriptyline was found to be considerably superior to placebo after six weeks and significantly so as early as two weeks after the start of treatment. The effects of the antidepressant were on the core symptoms of depression, and were apparent in all but the most mildly ill patients. The findings suggest that tricyclic antidepressants are of considerable therapeutic benefit to depressed patients in general practice.
摘要
在一项为期六周的双盲安慰剂对照试验中，纳入了普通诊所中的抑郁症患者，给予阿米替林治疗（中位剂量125毫克）。这些患者病情相对较轻，符合抑郁症诊断标准且在常规临床实践中适合使用抗抑郁药治疗。六周后发现阿米替林明显优于安慰剂，早在治疗开始两周后就有显著差异。抗抑郁药的作用针对抑郁症的核心症状，除了病情最轻微的患者外，在所有患者中都很明显。研究结果表明，三环类抗抑郁药对普通诊所中的抑郁症患者具有相当大的治疗益处。
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