Department of Radiation Oncology and Molecular Radiation Sciences, Johns Hopkins School of Medicine, Baltimore, Maryland.
Department of Radiation Oncology, Massachusetts General Hospital, Boston, Massachusetts.
Pediatr Blood Cancer. 2018 Jul;65(7):e27046. doi: 10.1002/pbc.27046. Epub 2018 Apr 6.
Proton therapy is a form of particle therapy with physical properties that provide a superior dose distribution compared to photons. The ability to spare healthy, developing tissues from low dose radiation with proton therapy is well known. The capability to decrease radiation exposure for children has been lauded as an important advance in pediatric cancer care, particularly for central nervous system (CNS) tumors. Favorable clinical outcomes have been reported and justify the increased cost and burden of this therapy. In this review, we summarize the current literature for proton therapy for pediatric CNS malignancies, with a focus on clinical outcomes to date.
质子治疗是一种粒子治疗形式，其物理特性可提供优于光子的剂量分布。质子治疗能够使健康、发育中的组织免受低剂量辐射的影响，这一点是众所周知的。降低儿童的辐射暴露已被称赞为儿科癌症治疗的重要进展，特别是对于中枢神经系统（CNS）肿瘤。已经报道了良好的临床结果，并证明了这种治疗方法增加的成本和负担是合理的。在这篇综述中，我们总结了目前关于儿童中枢神经系统恶性肿瘤质子治疗的文献，重点是迄今为止的临床结果。
