Matsumura I, Hashino M, Maruyama S, Yanaihara T, Nakayama T
Department of Obstetrics and Gynecology, Showa University School of Medicine, Tokyo.
Nihon Sanka Fujinka Gakkai Zasshi. 1987 Dec;39(12):2125-32.
Fetal adrenal gland is known to develop till term and decrease in size after birth. In this study, the size of the adrenal glands was evaluated by real time ultrasonography and steroid levels in the maternal and neonatal peripheral veins were measured by Gas chromatography-Mass spectrometry with application of deutrated steroids as internal standards. One hundred normal pregnant women at 28-40 weeks of gestation and ten cases of cesarean section, not labor, infants were selected for this study. The size of the fetal adrenal glands increased as gestation advanced. Levels of maternal 16DHA-S, P5-S and E3 correlated well with the length of the fetal adrenal glands. No correlation between the size of fetal adrenal gland and maternal DHA-S levels was noticed, except at 36-40 weeks of gestation. On the 7th day after birth, the neonatal adrenal glands were about 20% longer than at delivery. Levels of DHA-S, 16DHA-S, P5-S and 16P5-S in neonatal blood were 85%, 49%, 71% and 50% lower than at delivery during this period. In the present study, the relation between the adrenal steroid levels in maternal/neonatal serum and the size of the fetal/neonatal glands was demonstrated for the first time.
已知胎儿肾上腺会发育至足月，出生后体积减小。在本研究中，通过实时超声检查评估肾上腺大小，并使用氘代类固醇作为内标，采用气相色谱-质谱法测量母体和新生儿外周静脉中的类固醇水平。本研究选取了100名妊娠28 - 40周的正常孕妇以及10例剖宫产（非经产）婴儿。胎儿肾上腺大小随孕周增加而增大。母体16DHA - S、P5 - S和E3水平与胎儿肾上腺长度密切相关。除妊娠36 - 40周外，未发现胎儿肾上腺大小与母体DHA - S水平之间存在相关性。出生后第7天，新生儿肾上腺比分娩时约长20%。在此期间，新生儿血液中DHA - S、16DHA - S、P5 - S和16P5 - S水平分别比分娩时低85%、49%、71%和50%。在本研究中，首次证明了母体/新生儿血清中肾上腺类固醇水平与胎儿/新生儿肾上腺大小之间的关系。
