人附睾蛋白 4 在子宫内膜癌中的研究：荟萃分析。

Human epididymis protein 4 in endometrial cancer: A meta-analysis.

机构信息

Center for Gene Diagnosis, Zhongnan Hospital of Wuhan University, 169# Donghu Road, Wuhan 430071, China.

Personalized Drug Therapy Key Laboratory of Sichuan Province, Affiliated Hospital of University of Electronic Science and Technology of China, Sichuan Academy of Medical Sciences and Sichuan Provincial People's Hospital, Chengdu 610072, China.

出版信息

Clin Chim Acta. 2018 Jul;482:215-223. doi: 10.1016/j.cca.2018.03.040. Epub 2018 Apr 6.

DOI:10.1016/j.cca.2018.03.040

PMID:29630870

Abstract

BACKGROUND

Serum human epididymis protein 4 (HE4) is a potential marker for endometrial cancer (EC), however, the diagnostic value of HE4 for EC remains controversial. In this study, we performed a meta-analysis to estimate the diagnostic accuracy of serum HE4 for EC.

METHODS

Literature reports of the diagnostic accuracy of serum HE4 for EC were systematically identified using online data-bases. The meta-analysis was performed using STATA 12.0, Meta-Disc 1.4, and Review Manager 5.2.

RESULTS

A total of 4182 participants and 23 studies were included in our meta-analysis. The pooled sensitivity (SEN), specificity (SPE), positive likelihood ratio (PLR), negative likelihood ratio (NLR), diagnostic odds ratio (DOR), and area under the curve (AUC) were 0.65 (95% CI: 0.56-0.73), 0.91 (95% CI: 0.84-0.95), (95% CI: 4.38-12.64), 0.38 (95% CI: 0.31-0.47), 19.46 (95% CI: 11.61-32.62) and 0.84 (95% CI: 0.81 to 0.87), respectively. Our overall analysis suggested that HE4 is a useful diagnostic marker for EC. Subgroup analysis indicated that studies with benign disease controls showed higher diagnostic accuracies than those with healthy controls.

CONCLUSION

Serum HE4 may serve as a potential biomarker for EC diagnosis. Due to certain limitations, this conclusion should to be cautiously interpreted.

摘要

背景

血清人附睾蛋白 4（HE4）是子宫内膜癌（EC）的潜在标志物，然而，HE4 对 EC 的诊断价值仍存在争议。本研究通过荟萃分析评估血清 HE4 对 EC 的诊断准确性。

方法

系统检索在线数据库中关于血清 HE4 对 EC 诊断准确性的文献报告。采用 STATA12.0、Meta-Disc1.4 和 Review Manager5.2 进行荟萃分析。

结果

本荟萃分析共纳入 4182 名参与者和 23 项研究。汇总敏感性（SEN）、特异性（SPE）、阳性似然比（PLR）、阴性似然比（NLR）、诊断比值比（DOR）和曲线下面积（AUC）分别为 0.65（95%CI：0.56-0.73）、0.91（95%CI：0.84-0.95）、（95%CI：4.38-12.64）、0.38（95%CI：0.31-0.47）、19.46（95%CI：11.61-32.62）和 0.84（95%CI：0.81-0.87）。我们的综合分析表明，HE4 是 EC 诊断的有用标志物。亚组分析表明，以良性疾病为对照的研究显示出更高的诊断准确性，而以健康人群为对照的研究则较低。