Department of Psychiatry, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA; Duke University School of Medicine, Durham, NC, USA.
Veterans Affairs Medical Center, Durham, NC, USA; Department of Psychiatry, Duke University Medical Center, Durham, NC, USA.
Psychiatry Res. 2018 Jun;264:131-142. doi: 10.1016/j.psychres.2018.03.033. Epub 2018 Mar 20.
Relapse after discontinuation of ECT is significant in patients with schizophrenia. The purpose of this systematic review was to examine use of M-ECT in schizophrenia to guide clinical decision making for relapse prevention in schizophrenia. We reviewed studies examining the role of continuation (C-ECT) and maintenance electroconvulsive therapy (M-ECT) in schizophrenia. Following PRISMA guidelines, we included randomized controlled trials, open label trials, retrospective chart reviews, case reports, and case series in this review. We evaluated adjunctive pharmacological regimens; ECT treatment parameters, including frequency, duration of continued treatment, electrode placement; clinical outcomes including cognitive side effects and relapse rates from included studies. Our findings suggest M-ECT could provide an effective form of relapse prevention in these patients and persistent cognitive side effects are minimal.
电抽搐治疗（ECT）停止后复发在精神分裂症患者中是显著的。本系统综述的目的是检查精神分裂症中使用重复经颅磁刺激（rTMS）治疗以指导精神分裂症复发预防的临床决策。我们回顾了研究 rTMS 继续（C-ECT）和维持电抽搐治疗（M-ECT）在精神分裂症中的作用。根据 PRISMA 指南，我们将随机对照试验、开放标签试验、回顾性图表审查、病例报告和病例系列纳入本综述。我们评估了辅助药物治疗方案；ECT 治疗参数，包括频率、继续治疗的持续时间、电极放置；包括认知副作用和复发率在内的临床结果。我们的研究结果表明，M-ECT 可能为这些患者提供一种有效的预防复发的形式，且持续的认知副作用最小。
