促肾上腺皮质激素释放因子对促黄体生成素释放的抑制作用可能部分是通过下丘脑β-内啡肽的释放介导的。
Inhibition of LH release by CRF may be partially mediated through hypothalamic beta-endorphin release.
作者信息
Nikolarakis K E, Almeida O F, Herz A
机构信息
Department of Neuropharmacology, Max-Planck-Institut für Psychiatrie, Martinsried, F.R.G.
出版信息
NIDA Res Monogr. 1986;75:403-5.
Corticotropin releasing factor (CRF) given i.c.v. at doses of 0.02-2 nmol, significantly inhibited luteinising hormone (LH) secretion in castrate male rats. The luteinising hormone releasing hormone (LHRH) release from hypothalamic slices superfused in vitro with CRF (10(-12)M - 10(-8)M) was markedly reduced. In rats that had been infused with naloxone 2 days prior to testing with 0.2 nmol CRF, the effect of the CRF was significantly reduced. Together, these findings indicate that CRF inhibits LH secretion by inhibiting LHRH release from the hypothalamus, and that the latter action involves endogenous opioid peptides.
以0.02 - 2纳摩尔的剂量脑室内注射促肾上腺皮质激素释放因子（CRF），可显著抑制去势雄性大鼠的促黄体生成素（LH）分泌。在体外与CRF（10⁻¹²摩尔/升 - 10⁻⁸摩尔/升）一起灌注的下丘脑切片中，促黄体生成素释放激素（LHRH）的释放明显减少。在用0.2纳摩尔CRF进行测试前2天已注射纳洛酮的大鼠中，CRF的作用显著降低。这些研究结果共同表明，CRF通过抑制下丘脑释放LHRH来抑制LH分泌，并且后一种作用涉及内源性阿片肽。
Zotero 插件