• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

相似文献

1
Cushing's Disease - Quality of Life, Recurrence and Long-term Morbidity.库欣病——生活质量、复发及长期发病率
Eur Endocrinol. 2015 Apr;11(1):34-38. doi: 10.17925/EE.2015.11.01.34. Epub 2015 Apr 11.
2
Paediatric Cushing's disease: long-term outcome and predictors of recurrence.儿童库欣病：长期预后及复发的预测因素
Front Endocrinol (Lausanne). 2024 Jan 22;15:1345174. doi: 10.3389/fendo.2024.1345174. eCollection 2024.
3
Cushing's disease.库欣病
Handb Clin Neurol. 2014;124:221-34. doi: 10.1016/B978-0-444-59602-4.00015-0.
4
Repeat transsphenoidal surgery for Cushing's disease.库欣病的经蝶窦重复手术
J Neurosurg. 1989 Oct;71(4):520-7. doi: 10.3171/jns.1989.71.4.0520.
5
The role of bilateral adrenalectomy in the treatment of refractory Cushing's disease.双侧肾上腺切除术在难治性库欣病治疗中的作用。
Neurosurg Focus. 2015 Feb;38(2):E9. doi: 10.3171/2014.10.FOCUS14684.
6
A critical reappraisal of bilateral adrenalectomy for ACTH-dependent Cushing's syndrome.对促肾上腺皮质激素（ACTH）依赖性库欣综合征双侧肾上腺切除术的批判性重新评估。
Eur J Endocrinol. 2015 Oct;173(4):M23-32. doi: 10.1530/EJE-15-0265. Epub 2015 May 20.
7
Long-term outcomes of children treated for Cushing's disease: a single center experience.库欣病患儿治疗的长期结果：单中心经验。
Pituitary. 2016 Dec;19(6):612-624. doi: 10.1007/s11102-016-0756-8.
8
The use of postoperative ACTH levels as a marker for successful transsphenoidal microsurgery in Cushing's disease.使用术后促肾上腺皮质激素（ACTH）水平作为库欣病经蝶窦显微手术成功的标志物。
Zentralbl Neurochir. 2003;64(1):6-11. doi: 10.1055/s-2003-37145.
9
Results of repeated transsphenoidal surgery in Cushing's disease. Long-term follow-up.库欣病经蝶窦重复手术的结果。长期随访。
Endocrinol Nutr. 2014 Apr;61(4):176-83. doi: 10.1016/j.endonu.2013.10.008. Epub 2013 Dec 17.
10
Transsphenoidal microsurgery for Cushing's disease: initial outcome and long-term results.经蝶窦显微手术治疗库欣病：初始疗效及长期结果
J Clin Endocrinol Metab. 2004 Dec;89(12):6348-57. doi: 10.1210/jc.2003-032180.

引用本文的文献

1
Cushing's syndrome related to higher rates and earlier onset of cataract: A nationwide retrospective cohort study.库欣综合征与白内障的高发病率及发病年龄提前相关：一项全国性回顾性队列研究。
Graefes Arch Clin Exp Ophthalmol. 2025 May;263(5):1345-1353. doi: 10.1007/s00417-025-06752-6. Epub 2025 Jan 23.
2
Unmet needs on the current medical management of Cushing's syndrome: results from a Delphi panel of Italian endocrinologists.库欣综合征现行医学管理中未满足的需求：意大利内分泌学家德尔菲小组的研究结果。
J Endocrinol Invest. 2023 Sep;46(9):1923-1934. doi: 10.1007/s40618-023-02058-8. Epub 2023 Apr 19.
3
Recurrence after pituitary surgery in adult Cushing's disease: a systematic review on diagnosis and treatment.成人库欣病垂体手术后的复发：关于诊断和治疗的系统评价
Endocrine. 2020 Nov;70(2):218-231. doi: 10.1007/s12020-020-02432-z. Epub 2020 Aug 2.
4
Illustration of patient-reported outcome challenges and solutions in rare diseases: a systematic review in Cushing's syndrome.罕见病患者报告结局挑战及解决方案的图示：库欣综合征的系统评价
Orphanet J Rare Dis. 2018 Dec 19;13(1):228. doi: 10.1186/s13023-018-0958-4.

本文引用的文献

1
Clinical and biochemical manifestations of Cushing's.库欣综合征的临床和生化表现。
Pituitary. 2015 Apr;18(2):181-7. doi: 10.1007/s11102-014-0631-4.
2
The hypertension of Cushing's syndrome: controversies in the pathophysiology and focus on cardiovascular complications.库欣综合征的高血压：病理生理学争议及心血管并发症聚焦
J Hypertens. 2015 Jan;33(1):44-60. doi: 10.1097/HJH.0000000000000415.
3
Treatment effectiveness of pasireotide on health-related quality of life in patients with Cushing's disease.培高利特治疗库欣病患者健康相关生活质量的疗效。
Eur J Endocrinol. 2014 Jul;171(1):89-98. doi: 10.1530/EJE-13-1013. Epub 2014 Apr 23.
4
Long-term remission and recurrence rate in a cohort of Cushing's disease: the need for long-term follow-up.一组库欣病患者的长期缓解率和复发率：长期随访的必要性。
Pituitary. 2015 Feb;18(1):142-9. doi: 10.1007/s11102-014-0567-8.
5
Long-term remission and recurrence rates after first and second transsphenoidal surgery for Cushing's disease: care reality in the Munich Metropolitan Region.库欣病经蝶窦手术初次和再次治疗后的长期缓解率和复发率：慕尼黑大都市区的治疗现状。
Eur J Endocrinol. 2013 Dec 21;170(2):283-92. doi: 10.1530/EJE-13-0634. Print 2014 Feb.
6
Tuebingen CD-25 is a sensitive tool to investigate health-related quality of life in Cushing's disease patients in the course of the disease.图宾根 CD-25 是一种敏感的工具，可用于在库欣病患者疾病进展过程中调查与健康相关的生活质量。
Neuroendocrinology. 2013;98(3):188-99. doi: 10.1159/000355622. Epub 2013 Nov 6.
7
Smaller grey matter volumes in the anterior cingulate cortex and greater cerebellar volumes in patients with long-term remission of Cushing's disease: a case-control study.库欣病长期缓解患者的前扣带皮层灰质体积较小，小脑体积较大：一项病例对照研究。
Eur J Endocrinol. 2013 Oct 21;169(6):811-9. doi: 10.1530/EJE-13-0471. Print 2013 Dec.
8
Mortality in Cushing's syndrome: systematic analysis of a large series with prolonged follow-up.库欣综合征患者的死亡率：一项具有长期随访的大型系列研究的系统分析。
Eur J Endocrinol. 2013 Oct 8;169(5):715-23. doi: 10.1530/EJE-13-0569. Print 2013 Nov.
9
Mortality in Cushing's syndrome: data from 386 patients from a single tertiary referral center.库欣综合征患者的死亡率：来自一家三级转诊中心的 386 例患者的数据。
Eur J Endocrinol. 2013 Oct 1;169(5):621-7. doi: 10.1530/EJE-13-0320. Print 2013 Nov.
10
Glucocorticoid-induced osteoporosis: lessons from Cushing's syndrome.糖皮质激素诱导的骨质疏松症：库欣综合征的教训。
Clin Endocrinol (Oxf). 2013 Jul;79(1):1-11. doi: 10.1111/cen.12189. Epub 2013 Apr 13.

库欣病——生活质量、复发及长期发病率

Cushing's Disease - Quality of Life, Recurrence and Long-term Morbidity.

作者信息

Huguet Isabel, Ntali Georgia, Grossman Ashley, Karavitaki Niki

机构信息

Oxford Centre for Diabetes, Endocrinology and Metabolism, Churchill Hospital, Headington, UK.

Centre for Endocrinology, Diabetes and Metabolism, School of Clinical and Experimental Medicine, University of Birmingham, UK.

出版信息

Eur Endocrinol. 2015 Apr;11(1):34-38. doi: 10.17925/EE.2015.11.01.34. Epub 2015 Apr 11.

DOI:10.17925/EE.2015.11.01.34
PMID:29632565
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5819060/
Abstract

Cushing's disease (CD) is a rare disorder caused by an adrenocorticotropic hormone (ACTH)-secreting pituitary adenoma. Chronic exposure to hypercortisolism leads to significant morbidities, which may be only partially reversible after remission of the disease, as well as to impairment of the health-related quality of life (HRQoL) and an increase in mortality. Transsphenoidal surgery (TSS) is the treatment of choice, and recurrence rates vary widely, confirming the need for lifelong follow-up. This review summarises the studies performed on HRQoL, recurrence rates and morbidities in patients who have CD.

摘要

库欣病（CD）是一种由分泌促肾上腺皮质激素（ACTH）的垂体腺瘤引起的罕见疾病。长期暴露于高皮质醇血症会导致严重的发病情况，在疾病缓解后可能仅有部分可逆，还会损害健康相关生活质量（HRQoL）并增加死亡率。经蝶窦手术（TSS）是首选治疗方法，复发率差异很大，这证实了需要进行终身随访。本综述总结了对患有库欣病患者的健康相关生活质量、复发率和发病情况的研究。