库欣病——生活质量、复发及长期发病率
Cushing's Disease - Quality of Life, Recurrence and Long-term Morbidity.
作者信息
Huguet Isabel, Ntali Georgia, Grossman Ashley, Karavitaki Niki
机构信息
Oxford Centre for Diabetes, Endocrinology and Metabolism, Churchill Hospital, Headington, UK.
Centre for Endocrinology, Diabetes and Metabolism, School of Clinical and Experimental Medicine, University of Birmingham, UK.
出版信息
Eur Endocrinol. 2015 Apr;11(1):34-38. doi: 10.17925/EE.2015.11.01.34. Epub 2015 Apr 11.
Abstract
Cushing's disease (CD) is a rare disorder caused by an adrenocorticotropic hormone (ACTH)-secreting pituitary adenoma. Chronic exposure to hypercortisolism leads to significant morbidities, which may be only partially reversible after remission of the disease, as well as to impairment of the health-related quality of life (HRQoL) and an increase in mortality. Transsphenoidal surgery (TSS) is the treatment of choice, and recurrence rates vary widely, confirming the need for lifelong follow-up. This review summarises the studies performed on HRQoL, recurrence rates and morbidities in patients who have CD.
摘要
库欣病（CD）是一种由分泌促肾上腺皮质激素（ACTH）的垂体腺瘤引起的罕见疾病。长期暴露于高皮质醇血症会导致严重的发病情况，在疾病缓解后可能仅有部分可逆，还会损害健康相关生活质量（HRQoL）并增加死亡率。经蝶窦手术（TSS）是首选治疗方法，复发率差异很大，这证实了需要进行终身随访。本综述总结了对患有库欣病患者的健康相关生活质量、复发率和发病情况的研究。
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The hypertension of Cushing's syndrome: controversies in the pathophysiology and focus on cardiovascular complications.库欣综合征的高血压：病理生理学争议及心血管并发症聚焦
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