中枢性性早熟——管理与长期预后
Central Precocious Puberty - Management and Long-term Outcomes.
作者信息
Léger Juliane, Carel Jean-Claude
机构信息
Assistance Publique-Hôpitaux de Paris, Hôpital Robert Debré, Service d'Endocrinoiogie Diabetologie Pédiatrique, Centre de Référence des Maladies Endocriniennes Rares de la Croissance, F-75019 Paris, France.
Université Paris Diderot, Sorbonne Paris Cité, F-75019 Paris, France.
出版信息
Eur Endocrinol. 2015 Apr;11(1):45-46. doi: 10.17925/EE.2015.11.01.45. Epub 2015 Apr 11.
Abstract
Central precocious puberty (CPP) results from premature re-activation of the gonadotropic axis. CPP is much more common in girls than in boys and is idiopathic in most cases. In boys, precocious puberty is more likely to be linked to hypothalamic lesions (≈40%). Recent studies have implicated the inactivation of gene in 'idiopathic' CPP Gonadotropin-releasing hormone agonists are the standard treatment for progressive CPP.
摘要
中枢性性早熟（CPP）是由促性腺轴过早重新激活引起的。CPP在女孩中比在男孩中更为常见，且在大多数情况下是特发性的。在男孩中，性早熟更可能与下丘脑病变有关（约40%）。最近的研究表明，“特发性”CPP中基因失活。促性腺激素释放激素激动剂是进行性CPP的标准治疗方法。
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