Antão Esther-Maria, Wagner-Ahlfs Christian
Institut für Mikrobiologie und Tierseuchen, Zentrum für Infektionsmedizin, Freie Universität Berlin, Robert-von-Ostertag-Str. 7-13, 14163, Berlin, Deutschland.
BUKO Pharma-Kampagne, Hasseer Str. 12, 24113, Kiel, Deutschland.
Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz. 2018 May;61(5):499-506. doi: 10.1007/s00103-018-2726-y.
Without doubt, drug resistance is now one of the greatest health threats of our time. Not even 100 years after the discovery of the first antibiotics that saved human lives, we find ourselves threatened by the thought of a post-antibiotic era. Currently it is estimated that around 700,000 people die annually as a consequence of drug-resistant infections. Antibiotic resistance is a natural phenomenon with bacteria having devised several ways of combating the antibiotic attack. Rather than being a spontaneous event, resistance becomes an integral part of the microbe's genetic make-up, spreading further between and across species. However, the misuse and overuse of antibiotics over the years has in fact allowed for resistant bacteria to thrive, while slowly wiping out sensitive bacteria. Spreading awareness and proper information in the community about the risks and consequences of a rapidly developing antibiotic resistance is essential in tackling this global problem. In working together as an entire community, we can find long-lasting solutions. The One Health concept includes human and veterinary medical sectors, the environmental sector, as well as various decision-making bodies that include individual action as well as national and international policymakers. The role of stakeholders like pharmaceutical companies and agriculturists must be given importance, too, thinking all the while in a global context. Only this way will we find solutions for sustainable healthcare and together help slow down the process of antibiotic resistance.
毫无疑问，耐药性是我们这个时代最大的健康威胁之一。在发现拯救人类生命的首批抗生素还不到100年的时间里，我们就发现自己受到了后抗生素时代的威胁。目前估计，每年约有70万人死于耐药性感染。抗生素耐药性是一种自然现象，细菌已经想出了几种对抗抗生素攻击的方法。耐药性并非是一个自发事件，而是微生物基因组成的一个组成部分，在物种之间和跨物种之间进一步传播。然而，多年来抗生素的滥用和过度使用实际上使得耐药细菌得以繁衍，同时慢慢地消灭了敏感细菌。在社区中传播关于快速发展的抗生素耐药性的风险和后果的意识及正确信息，对于解决这个全球性问题至关重要。作为一个整体社区共同努力，我们才能找到持久的解决方案。“同一健康”概念涵盖人类和兽医学领域、环境领域，以及包括个人行动以及国家和国际政策制定者在内的各种决策机构。制药公司和农业从业者等利益相关者的作用也必须得到重视，同时始终从全球角度考虑问题。只有这样，我们才能找到可持续医疗保健的解决方案，并共同帮助减缓抗生素耐药性的进程。
