Department of Geriatric Medicine, Seinäjoki Central Hospital, Hanneksenrinne 7, 60220, Seinäjoki, Finland.
Science Center, Pirkanmaa Hospital District, Tampere, Finland.
Aging Clin Exp Res. 2019 Jan;31(1):75-83. doi: 10.1007/s40520-018-0946-5. Epub 2018 Apr 9.
Multiple factors contribute to elevated post-void residual urine volumes (PVR), but they may indicate detrusor underactivity (DU), especially in older women. The aim here was to examine factors associated with and prognostic significance of elevated PVR in a geriatric post-hip fracture assessment in a female population.
Consecutive female hip fracture patients (n = 409) aged 65 years and older were included. PVR was measured by bladder scanner. PVR of 160 ml or more was deemed elevated. Age-adjusted univariate logistic regression analyses were conducted to examine the association of the domains of the comprehensive geriatric assessment (CGA) with elevated PVR. Cox proportional hazards model was used to determine the age-adjusted association of an elevated PVR with 1-year mortality.
Of the patients, 64 (15.6%) had elevated PVR. Having urinary or fecal incontinence, difficulties in physical activities of daily living, malnutrition, poor performance on Timed Up and Go and Elderly Mobility Scale were significantly associated with elevated PVR. Difficulties in instrumental activities of daily living, renal dysfunction, constipation, polypharmacy, nocturia, cognitive impairment and depressive mood were not associated with elevated PVR. Elevated PVR significantly increased the risk of mortality 1 year post hip fracture.
Elevated PVR is relatively common in older female hip fracture patients and associated with physical functioning, malnutrition and risk of mortality. Even though a causal relationship cannot be confirmed, the findings may suggest a relationship between DU and physical frailty. PVR deserves to be included in the CGA of frail older patients including women.
多种因素可导致残余尿量(PVR)升高,但这些因素可能表明逼尿肌活动低下(DU),尤其是老年女性。本研究旨在探讨老年女性髋部骨折评估中 PVR 升高的相关因素及其预后意义。
连续纳入 409 例年龄≥65 岁的女性髋部骨折患者。采用膀胱扫描仪测量 PVR。PVR 超过 160ml 被认为升高。采用年龄调整的单因素逻辑回归分析,研究综合老年评估(CGA)各领域与 PVR 升高的相关性。采用 Cox 比例风险模型,确定 PVR 升高与 1 年死亡率的年龄调整相关性。
409 例患者中,64 例(15.6%)PVR 升高。尿失禁或粪便失禁、日常生活活动困难、营养不良、Timed Up and Go 测试和老年移动能力量表评分差与 PVR 升高显著相关。日常生活活动的工具性部分困难、肾功能障碍、便秘、多药治疗、夜尿症、认知障碍和抑郁情绪与 PVR 升高无关。PVR 升高显著增加髋部骨折后 1 年的死亡率风险。
老年女性髋部骨折患者中 PVR 升高较为常见,与身体功能、营养不良和死亡风险相关。尽管不能确定因果关系,但这些发现可能表明 DU 与身体虚弱之间存在关系。PVR 值得纳入虚弱老年患者(包括女性)的 CGA 中。