Pediatric Pharmacology and Pharmacometrics Research Center, University Children's Hospital Basel, Basel, Switzerland.
Certara, Princeton, New Jersey, USA.
Clin Pharmacol Ther. 2018 Dec;104(6):1110-1124. doi: 10.1002/cpt.1084. Epub 2018 May 6.
During recent years there has been a surge in developing and applying physiologically based pharmacokinetic (PBPK) models in pregnant women to better understand and predict changes in drug pharmacokinetics throughout pregnancy. As a consequence, the number of publications focusing on pregnancy PBPK models has increased substantially. However, to date these models, especially across various platforms, have not been systematically evaluated. Hence, this review aims to assess published PBPK models in pregnancy used for therapeutic purposes.
近年来，人们在开发和应用基于生理学的药代动力学（PBPK）模型以更好地理解和预测整个妊娠期间药物药代动力学变化方面取得了突飞猛进的发展。因此，专注于妊娠 PBPK 模型的出版物数量大大增加。然而，迄今为止，这些模型，特别是在各种平台上，尚未得到系统评估。因此，本综述旨在评估用于治疗目的的已发表的妊娠 PBPK 模型。
