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牙髓治疗期间次氯酸盐意外致神经损伤——一例报告

Hypochlorite accident during wndodontic therapy with nerve damage - A case report.

作者信息

Perotti Silvia, Bin Paola, Cecchi Rossana

机构信息

Univeristy of Brescia.

University of Brescia.

出版信息

Acta Biomed. 2018 Mar 27;89(1):104-108. doi: 10.23750/abm.v89i1.6067.

DOI:10.23750/abm.v89i1.6067
PMID:29633752
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6357615/
Abstract

Endodontic therapy is a routinely practised clinical procedure with few reported complications but, as a bleaching agent, inadvertent spillage of sodium hypochlorite beyond the root canal system may result in extensive soft tissue or nerve damage, and even airway compromise. Although very rare, complications arising from hypochlorite extrusion beyond the root apex are described. NaOCl causes oxidation of protein and lipid membrane and causes necrosis, hemolysis and dermal ulcerations (2-4). Neurological complication are very rare. Paraesthesia and anaesthesia may affect the mental, inferior dental and infra-orbital branches of the trigeminal nerve and normal sensation may take many months to  completely resolve (6, 7). Nerve damage (the buccal branch) was described in 2005 by Witton et al. (8) and patients exhibited a loss of the naso-labial groove and a down turning of the angle of the mouth and the motor function was regained after several months. We present a case in which the extrusion of NaOCl solution during endodontic therapy led to important destructive effects on soft tissues and nerves. The arisen medico legal issues are discussed.

摘要

牙髓治疗是一种常规实施的临床操作,报告的并发症较少,但作为一种漂白剂,次氯酸钠意外溢出根管系统可能会导致广泛的软组织或神经损伤,甚至气道受损。尽管非常罕见,但仍有关于次氯酸盐从根尖孔挤出引起并发症的描述。次氯酸钠会导致蛋白质和脂质膜氧化,引起坏死、溶血和皮肤溃疡(2-4)。神经并发症非常罕见。感觉异常和麻醉可能会影响三叉神经的颏神经、下牙槽神经和眶下神经分支,正常感觉可能需要数月才能完全恢复(6,7)。2005年,Witton等人描述了神经损伤(颊支)(8),患者出现鼻唇沟消失和口角下垂,运动功能在数月后恢复。我们报告一例牙髓治疗期间次氯酸钠溶液挤出导致软组织和神经受到严重破坏的病例。并对由此引发的医疗法律问题进行了讨论。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8aa6/6357615/328dd21d64af/ACTA-89-104-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8aa6/6357615/328dd21d64af/ACTA-89-104-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8aa6/6357615/328dd21d64af/ACTA-89-104-g001.jpg

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Root canal complications: 'the hypochlorite accident'.根管并发症:“次氯酸盐事故”
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