手性双功能相转移催化剂在无碱和富水条件下对硝基烯烃的对映选择性胺化反应。
Enantioselective amination of nitroolefins under base-free and water-rich conditions using chiral bifunctional phase-transfer catalysts.
机构信息
Department of Medicinal Chemistry, School of Pharmacy, The Fourth Military Medical University, Changle West Road 169, Xi'an, 710032, P. R. China.
出版信息
Org Biomol Chem. 2018 Apr 25;16(16):3012-3017. doi: 10.1039/c8ob00583d.
PMID:29633771
Abstract
The direct enantioselective amination of nitroolefins has been performed with l-tert-leucine-derived squaramide-scaffold bifunctional phase-transfer catalysts under base-free and water-rich conditions with low catalyst loading (0.5-1 mol%) to provide 2-aminonitroalkanes in good yields (up to 96%) and enantioselectivities (up to 93% ee).
摘要
在无碱和富水条件下，使用 l-叔亮氨酸衍生的双功能席夫碱型手性相转移催化剂，以低催化剂负载量（0.5-1mol%）直接对硝基烯烃进行对映选择性胺化反应，以良好的收率（高达 96%）和对映选择性（高达 93%ee）得到 2-氨基硝基烷烃。
Zotero 插件