Asgari Majid Ali, Besharat Sara, Bakhtiyari Mahmood, Alirezaei Amirhesam
From the Urology and Nephrology Research Center, Shahid Modarress Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Exp Clin Transplant. 2019 Dec;17(6):819-822. doi: 10.6002/ect.2017.0228. Epub 2018 Apr 9.
En bloc kidney transplants of small pediatric kidneys into adult recipients have been shown to have outcomes similar to transplants from standard adult deceased donors. Here, we report a 27-year-old male patient with successful repair of bilateral ureteral stricture 3 years after en bloc kidney transplant at the Shahid Modarres Hospital (Tehran, Iran). The patient received an en bloc deceased kidney donation from a 9-month-old infant. An end-to-end anastomosis of the aorta to the internal iliac artery and an end-to-side external iliac vein anastomosis to vena cava were performed. At an outpatient visit about 2.5 years later, the patient showed increasing levels of creatinine from 1.1 to 1.8 mg/dL compared with measurements at his 2-month visit. A computed tomography scan performed without any contrast agent at that time confirmed the existence of hydronephrosis in both the medial and lateral kidneys. A nephrostography showed a ureteral stricture. Because endoscopic surgery for ureteral dilatation was not successful, the decision was made to perform ureteral repair by the open surgical technique. The short length of the ureters resulted in the lateral renal pelvis being anastomosed to the bladder by flap (Boari flap). The ureter of the patient's native kidney was transected in the middle portion, and the distal ureter was anastomosed to the medial renal pelvis using the end-to-end method. Here, we showed that, despite limited experiences with pediatric donors, en bloc kidney transplant can be performed under the guidance of experienced surgical techniques and precise postoperative follow-up.
将小儿小肾脏整块移植给成年受者已被证明其结果与来自标准成年已故供者的移植相似。在此,我们报告一名27岁男性患者,在伊朗德黑兰沙希德·莫达雷斯医院接受整块肾脏移植3年后,双侧输尿管狭窄成功修复。该患者接受了一名9个月大婴儿的整块已故肾脏捐赠。进行了主动脉与髂内动脉的端端吻合以及髂外静脉与腔静脉的端侧吻合。在大约2.5年后的一次门诊就诊时,与2个月时的测量值相比,患者的肌酐水平从1.1 mg/dL升至1.8 mg/dL。当时进行的无造影剂计算机断层扫描证实双侧肾脏均存在肾积水。肾造影片显示输尿管狭窄。由于输尿管扩张的内镜手术未成功,决定采用开放手术技术进行输尿管修复。输尿管较短,导致外侧肾盂通过皮瓣(博阿里皮瓣)与膀胱吻合。患者自体肾脏的输尿管在中部横断,远端输尿管采用端端法与内侧肾盂吻合。在此,我们表明,尽管小儿供者的经验有限,但在经验丰富的手术技术和精确的术后随访指导下,整块肾脏移植仍可进行。