Ogunlaja Olumuyiwa O, Moodley Roshila, Baijnath Himansu, Jonnalagadda Sreekantha B
Acta Pol Pharm. 2016 Nov;73(6):1593-1600.
Ficus buit-davyi, (Moraceae), is an endemic species of South Africa. In this study, a phytochemical analysis of the leaves and stem bark of F. burt-davyi resulted in the isolation of five triterpenes (lupeol, lupeol acetate, β-sitosterol, stigmasterol and campesterol), one carotenoid (lutein), a pheophytin (phytyl-7-ethyl-25- (methoxycarbonyl)-3,8,13,17-tetramethyl-26-oxo- 12-vinyl-17,18-dihydro-2,20-ethanoporphyrin- 1 8-propanoate or pheophytin a) and one flavonoid (+)-catechin). The in viti antioxidant study of the methanol extracts of leaves and stem bark, (+)-catechin and pheophytin a using the 1,1-diphenyl-1-picrylhydrazyl (DPPH) free radical scavenging assay, ferric reducing antioxidant power (FRAP) assay and hydrogen peroxide (H202) assay showed significantly higher (p < 0.05) antioxidant activity for the methanol extract of the stem bark than the leaves, with IC55 values (in μg/mL) of 58.28 ? 5.05 for DPPH, 46.09 ± 0.06 for FRAP and 151.03 ± 1.60 pg/mL for H₂0₂,. The results suggest that the plant can be used as a therapeutic agent in alternative medicine for oxidative stress related degenerative diseases.
布氏榕（桑科）是南非的特有物种。在本研究中，对布氏榕的叶和茎皮进行了植物化学分析，从中分离出五种三萜类化合物（羽扇豆醇、羽扇豆醇乙酸酯、β-谷甾醇、豆甾醇和菜油甾醇）、一种类胡萝卜素（叶黄素）、一种脱镁叶绿素（叶绿基-7-乙基-25-（甲氧基羰基）-3,8,13,17-四甲基-26-氧代-12-乙烯基-17,18-二氢-2,20-亚乙基卟啉-1,8-丙酸酯或脱镁叶绿素a）和一种黄酮类化合物（+）-儿茶素。使用1,1-二苯基-2-苦基肼（DPPH）自由基清除试验、铁还原抗氧化能力（FRAP）试验和过氧化氢（H₂O₂）试验对叶和茎皮的甲醇提取物、（+）-儿茶素和脱镁叶绿素a进行体外抗氧化研究，结果表明，茎皮甲醇提取物的抗氧化活性显著高于叶（p<0.05），DPPH的IC₅₀值（以μg/mL计）为58.28±5.05，FRAP为46.09±0.06，H₂O₂为151.03±1.60μg/mL²。结果表明该植物可作为治疗与氧化应激相关的退行性疾病替代医学中的治疗剂使用。
