Babaeizadeh Simin, Heydarnejhad Saeed, Pirbalouti Abdollah Ghasemi, Khamesipoor Faham, Moghtadaei-Khorasgani Elham, Heydari-Soureshjani Parisa
Acta Pol Pharm. 2016 Nov;73(6):1615-1622.
Bum wound is one of the most common complications and remains a major public health issue affecting all ages groups in both developed and developing countries. This study was aimed to evaluate the extract from Thymus daenensis and silver sulfadiazine on healing bum wounds in mice. In this experimental study, the ethanol extract from the aerial parts of T. daenensis (Lamiaceae) was used. Second-degree bum wounds were induced in three groups of eight Balb/C mice each. Group-I: the animals were treated with simple cream (control), Group-II: the animals were treated with simple cream containing the herb extract, and Group-III: the animals received the standard drug (silver sulfadiazine). The experimental groups were evaluated based on wound area, epithelialization time and histopathological characteristics. There were significant differences in surface area and the period of bum wound healing between the groups, particularly among Group-II when the animals received the extract of T. daenensis in comparison with control. At the 18" day, there was no significant improvement in healing percentage of the herb treated (94.6%) in comparison to the animals receiving the standard drug (95.8%). The best results of histopathological investigation were obtained with the extract of T. daenensis, when compared to the other group as well as to the control and standard drug. The herbal cream experimentally and histopathologically revealed a bum wound healing activity probably due to the antioxidant and anti-inflammatory activity of its phytochemical contents, especially phenolic compounds. Therefore, T. daenensis accelerated wound healing in mice and thus supports its traditional use.
烧伤创面是最常见的并发症之一，仍然是一个影响发达国家和发展中国家所有年龄段人群的重大公共卫生问题。本研究旨在评估百里香提取物和磺胺嘧啶银对小鼠烧伤创面愈合的影响。在本实验研究中，使用了唇形科植物百里香地上部分的乙醇提取物。将三组每组八只Balb/C小鼠诱导形成二度烧伤创面。第一组：动物用单纯乳膏治疗（对照组）；第二组：动物用含有草药提取物的单纯乳膏治疗；第三组：动物接受标准药物（磺胺嘧啶银）治疗。根据创面面积、上皮化时间和组织病理学特征对实验组进行评估。各组之间，尤其是第二组（动物接受百里香提取物）与对照组相比，烧伤创面愈合的表面积和时间存在显著差异。在第18天，与接受标准药物治疗的动物（95.8%）相比，接受草药治疗的动物（愈合率94.6%）的愈合率没有显著提高。与其他组以及对照组和标准药物相比，百里香提取物的组织病理学研究结果最佳。实验和组织病理学结果表明，草药乳膏具有烧伤创面愈合活性，这可能归因于其植物化学成分，尤其是酚类化合物的抗氧化和抗炎活性。因此，百里香可加速小鼠创面愈合，从而支持其传统用途。
