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[泌尿系统不同部位结石完全清除后的复发时间。五年随访研究]

[Time to recurrence after complete removal of calculi from different parts of the urinary system. five-year follow-up study].

作者信息

Kutluev M M, Safiullin R I, Mochalov K S

机构信息

Bashkir State Medical University, Urological department, Ufa, Russia.

Bashkir State Medical University, Central Medical and Scientists Laboratory, Ufa, Russia.

出版信息

Urologiia. 2018 Mar(1):20-24.

Abstract

INTRODUCTION

The usage of minimally invasive technologies (MIT), such as: extracorporeal shock wave lithotripsy (ESWL), transurethral ureterolithotripsy (URS), retrograde intrarenal surgery (RIRS), percutaneous nephrolithotripsy (PNL), allows to remove the stones from the calyx and pelvis system with 71- 96% of patients, and those from the ureter in 96.2% cases. However, a high incidence of stone recurrences (35-75%) demands the necessity of repeated lithotripsies and the search of the most appropriate methods of lithotripsy for reduction this indicator. The main goal. To determine the number of patients with recurrence of stone formation during five years after different types of lithotripsy in different parts of the urinary system.

MATERIALS AND METHODS

The results of the process were analyzed with 491 patients, who had been devided into two groups: group I - 358 patients suffering from the concrements of the ureter; group II - 133 patients having stones in kidney.

RESULTS

According to the age criterion, the sample data did not differ from each other (50 years for both groups (p=0.576). The initial number of lithotripsies with complete removal of stones was 80.7% in group I and 70.7% in gr. II, the repeated lithotripsy with usage of the same method was 5.9% and 12.8%, respectively. The usage of an additional method in repeated lithotripsy was necessary in 13.4% and 16.5% of cases respectively. There were differences between the sizes of stones in groups (p<0.0001), besides both groups showed the difference in recurrence time of stone formation (p=0,014). In gr. I weak negative correlation (-0.28) between age and time of recurrence was revealed. The age difference between men and women in both groups (p=0.00001 and p=0.0492, respectively) was found. There occurred differences in the size of stones in men and women groups (p=0.0000001 and p=0.0000001, respectively) and in the time of recurrence between men and women in I gr. (p=0.043). Most of stones were compose of CaOx, the second most important element was Uric Acid. All this testifies to peculiarities of the diet in the region of residence of the patients under control - the Republic of Bashkortostan, where people generally use meat and milk products.

DISCUSSION

The usage of MIT opened the possibility of complete stone removal from the urinary system with the most sparing technique. The lithotripsy of stones with any composition having been conducted, additional stone crushing is carried out with 21-59% of patients within 5 years. The investigation of patients detected a great number of recurrences of stones in the kidney stones group.

CONCLUSION

  1. After lithotripsy the recurrences during two years did not exceed 4,2% with patients in gr. I and 8,2% in gr. II patients. 2. Significant dependence of recurrent stone formation of gender composition was identified in gr. I and the time of recurrence was less in women. 3. The quantity of CaOx urolithiasis corresponds to global indicators. However, a large number of stones with Uric Acid in the composition indicates possible peculiarities of the patients diet. 4. The highest number of recurrences were in patients with CaOx (42.3%) and CaOx with CaF in the composition (23.1%), and in third place were patients with uric acid stones (19.2%).
摘要

引言

微创技术(MIT)的应用,如体外冲击波碎石术(ESWL)、经尿道输尿管碎石术(URS)、逆行肾内手术(RIRS)、经皮肾镜碎石术(PNL),能使71 - 96%的患者从肾盂和肾盏系统取出结石,96.2%的患者从输尿管取出结石。然而,结石复发率较高(35 - 75%),这就需要重复进行碎石术,并寻找最合适的碎石方法以降低该指标。主要目标:确定泌尿系统不同部位采用不同类型碎石术后五年内结石复发患者的数量。

材料与方法

分析了491例患者的治疗结果,这些患者被分为两组:第一组 - 358例患有输尿管结石的患者;第二组 - 133例患有肾结石的患者。

结果

根据年龄标准,样本数据无差异(两组均为50岁,p = 0.576)。结石完全清除的初次碎石率在第一组为80.7%,在第二组为70.7%,采用相同方法的重复碎石率分别为5.9%和12.8%。分别有13.4%和16.5%的病例在重复碎石时需要采用额外的方法。两组结石大小存在差异(p < 0.0001),此外,两组在结石形成的复发时间上也存在差异(p = 0.014)。在第一组中,年龄与复发时间之间存在弱负相关(-0.28)。发现两组中男性和女性的年龄存在差异(分别为p = 0.00001和p = 0.0492)。男性和女性组的结石大小存在差异(分别为p = 0.0000001和p = 0.0000001),且第一组中男性和女性的复发时间存在差异(p = 0.043)。大多数结石由草酸钙组成,其次重要的成分是尿酸。所有这些都证明了受控制患者居住地区(巴什科尔托斯坦共和国)的饮食特点,那里的人们普遍食用肉类和奶制品。

讨论

微创技术的应用为以最微创的技术从泌尿系统完全清除结石提供了可能。对任何成分的结石进行碎石术后,21 - 59%的患者在5年内需要进行额外的碎石。对患者的调查发现肾结石组结石复发数量较多。

结论

  1. 碎石术后,第一组患者两年内的复发率不超过4.2%,第二组患者为8.2%。2. 在第一组中确定了结石复发与性别组成有显著相关性,且女性的复发时间较短。3. 草酸钙尿路结石的数量与全球指标相符。然而,大量结石含有尿酸表明患者饮食可能存在特殊之处。4. 复发率最高的是草酸钙结石患者(42.3%)和含有草酸钙与氟化钙的结石患者(23.1%),排在第三位的是尿酸结石患者(19.2%)。

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